Catalytic Asymmetric Synthesis of cis-Vicinal Diamine Derivatives

Significance

Optically pure vicinal diamines are important building blocks in medicinal chemistry. This article focuses on the synthesis of unsymmetrical 1,2-cis-diamines in good yields and enantioselectivities via an asymmetric N-allylation of the parent meso compound using a chiral π-allyl Trost catalyst.