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Synfacts 2006(9): 0874-0874
DOI: 10.1055/s-2006-942050
DOI: 10.1055/s-2006-942050
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of Pelitrexol
S. Hu*, S. Kelly, S. Lee, J. Tao, E. Flahive
Pfizer Global ReseaRch and Development, La Jolla, USA
Further Information
Publication History
Publication Date:
23 August 2006 (online)
Significance
Pelitrexol is an antiangiogenesis agent that inhibits glycinamide ribonucleotide formyltransferase. Appendage of a labile oxalamic ester (blue) greatly enhanced the stereodifferentiation of the enzymatic resolution of the terminal ester (red) which is six bonds away from the stereogenic center in A.