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Synfacts 2007(1): 0009-0009  
DOI: 10.1055/s-2006-955655
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (+)-Gigantecin

Contributor(s): Philip Kocienski, Fiona Black
T. R. Hoye*, B. M. Eklov, J. Jeon, M. Khoroosi
University of Minnesota, Minneapolis, USA
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Publication History

Publication Date:
15 December 2006 (online)

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Significance

(+)-Gigantecin is a highly cytotoxic natural product. The unusual nonadjacent bis-THF-containing skeleton is constructed via a one-pot cross-metathesis/ring-closing metathesis cascade.