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Synfacts 2007(1): 0048-0048  
DOI: 10.1055/s-2006-955730
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Au(I)-Catalyzed Diastereoselective Tandem Addition/Carbocyclization

Contributor(s): Mark Lautens, Yann Béthuel, L15606
P. Y. Toullec, E. Genin, L. Leseurre, J.-P. Genêt*, V. Michelet*
Ecole Nationale Supérieure de Chimie de Paris
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Publication History

Publication Date:
15 December 2006 (online)

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Significance

The authors report on the first intermolecular addition of aromatic rings to unactivated alkenes. The reaction proved to be applicable to a wide range of enyne substrates and with various aromatic and heteroaromatic nucleophiles.