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Synfacts 2007(2): 0220-0220
DOI: 10.1055/s-2006-955775
DOI: 10.1055/s-2006-955775
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York
Suzuki-Miyaura Reactions Using a Polymer-Supported DABCO-Pd Complex
J.-H. Li*, X.-C. Hu, Y.-X. Xie
Hunan Normal University, Changsha, P. R. of China
Further Information
Publication History
Publication Date:
23 January 2007 (online)
Significance
Polymer-supported DABCO-palladium complex 4 was synthesized and found to promote the Suzuki-Miyaura cross-coupling reaction. Thus, the reaction of Merrifield resin 1 with DABCO 2 in acetone for 24 h gave the polymer-supported DABCO 3. After treatment of 3 with Pd(OAc)2, the resulting resin was filtered and rinsed with diethyl ether and MeOH to afford the polymer-supported DABCO-palladium complex 4. The Suzuki-Miyaura cross-coupling reactions of bromo- and chloroarenes with aryl boronic acids were carried out in the presence of complex 4 to give the corresponding biaryl products in high yield (17 examples, 85-96% yield).