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Synfacts 2007(3): 0238-0238  
DOI: 10.1055/s-2007-968197
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of ent-Clavilactone B

Contributor(s): Philip Kocienski, Indu Dager
I. Larrosa, M. I. Da Silva, P. M. Gómez, P. Hannen, E. Ko, S. R. Lenger, S. R. Linke, A. J. P. White, D. Wilton, A. G. M. Barrett*
Imperial College, London and , AstraZeneca, Bristol, UK
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Publication History

Publication Date:
20 February 2007 (online)

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Significance

Clavilactones A, B and C, isolated from the fungus Clitocybe clavipes, are potent tyrosine kinase inhibitors and possess antifungal and antibacterial activities. This is the first reported asymmetric synthesis of clavilactone B which features a three-component benzyne coupling reaction.