Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2007(3): 0338-0338
DOI: 10.1055/s-2007-968221
DOI: 10.1055/s-2007-968221
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York
Solid-Phase Synthesis of Disubstituted 2-Imidazolidinethiones
H. S. Jeon, J. H. Yoo, J. N. Kim, T. H. Kim*
Chonnam National University, Gwangju, Korea
Further Information
Publication History
Publication Date:
20 February 2007 (online)
Significance
Solid-phase synthesis of 2-imidazolidinethiones 6 was demonstrated. Thus, ArgoGel-CHO resin 1 was coupled with several amino alcohols to give resin-supported ethanolamines 2. Isothiocyanates 3 were attached to resin 2 to give the corresponding N-(2-hydroxyethyl)thioureas 4. The intramolecular cyclization of 4 under Mitsunobu conditions afforded the N-cyclized products 5. The resulting compounds 5 were converted via cleavage of polymer supports with TFA into 2-imidazolidinethiones 6.