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Synfacts 2007(3): 0298-0298  
DOI: 10.1055/s-2007-968244
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Tandem Cyclopropanation-Cope Rearrangement for Fused-Ring Frameworks

Contributor(s): Hisashi Yamamoto, Joshua P. Abell
H. Kusama, Y. Onizawa, N. Iwasawa*
Tokyo Institute Of Technology, Japan
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Publication History

Publication Date:
20 February 2007 (online)

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Significance

In a previous study on the W(CO)5(L)-catalyzed cyclization reaction, the authors expected that the cyclopropyl carbene intermediate could be further utilized in a Cope rearrangement to form a seven-membered ring system. As predicted, the authors demonstrated this reaction catalyzed by W(CO)5 and Et3N to form various useful bicycle[5.3.0]decanes.