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Synfacts 2007(4): 0416-0416  
DOI: 10.1055/s-2007-968328
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Pd-Catalyzed Cyanation of Aryl Chlorides with K4[Fe(CN)6]

Contributor(s): Paul Knochel, Andrei Gavryushin
T. Schareina, A. Zapf, W. Mägerlein, N. Müller, M. Beller*
Leibniz-Instiut für Katalyse e.V. an der Universität Rostock and Saltigo GmbH, Leverkusen, Germany
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Publication History

Publication Date:
23 March 2007 (online)

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Significance

The authors describe a new general protocol for the Pd-catalyzed cyanation of various aryl chlorides. In the contrast to previously known methods, their approach uses completely non-toxic and inexpensive potassium hexacyano­ferrate(II) as the cyanide source. The reaction proceeds in the presence of only 0.25-0.5 mol% of the palladium catalyst and is not sensitive to small amounts of water. This method is complementary to the cyanation of aryl bromides, previously described by the group of Beller.