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Synfacts 2007(7): 0673-0673  
DOI: 10.1055/s-2007-968599
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Ipomoeassin E

Contributor(s): Philip Kocienski
A. Fürstner*, T. Nagano
Max-Planck-Institut für Kohlenforschung, Mülheim/Ruhr, Germany
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Publication History

Publication Date:
22 June 2007 (online)

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Significance

Ipomoeassin E, a metabolite of the morning glory Ipomoea squamosa, inhibits the A2780 human ovarian cancer cell line (IC50 = 35 nM). The macrocycle was constructed efficiently from E by a ring-closing olefin-metathesis reaction using the Grubbs II catalyst F.