Synthesis of (+)-Madindolines A and B

doi:10.1055/s-2007-968604

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Synfacts 2007(7): 0672-0672
DOI: 10.1055/s-2007-968604

Synthesis of Natural Products and Potential Drugs

Synthesis of (+)-Madindolines A and B

Contributor(s): Philip Kocienski, Zofia Komsta
L. Wan, M. A. Tius*
University of Hawaii and the Cancer Research Center of Hawaii, Honolulu, USA

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Publication History

Publication Date:
22 June 2007 (online)

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Significance

Madindolines A and B selectively inhibit growth of interleukine-6 dependent cells. The main steps of this synthesis are (1) an allene-ether Nazarov cyclization and (2) an intermolecular Mannich reaction.