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Synfacts 2007(7): 0674-0674  
DOI: 10.1055/s-2007-968605
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Breast Cancer Cell Migration Inhibitor

Contributor(s): Philip Kocienski, Zofia Komsta
B. B. Metaferia, L. Chen, H. L. Baker, X.-Y. Huang, C. A. Bewley*
National Institutes of Health, Bethesda and Cornell University, New York, USA
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Publication History

Publication Date:
22 June 2007 (online)

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Significance

Synthetic macrolide F is an inhibitor of tumour cell migration of certain cancer cells. This short and efficient synthesis afforded access to five other analogues that were screened against various cancer cell lines.