Download PDF
Synfacts 2007(7): 0679-0679  
DOI: 10.1055/s-2007-968608
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Formal Synthesis of (+)-Estrone

Contributor(s): Philip Kocienski
D. Soorukram, P. Knochel*
Ludwig-Maximilians Universität München, Germany
Further Information

Publication History

Publication Date:
22 June 2007 (online)

    Permissions and Reprints

Significance

The synthesis of estrone has been a right of passage for many of the great and good in organic chemistry for more than 50 years. In this latest formal synthesis by Soorukram and Knochel, a novel copper(I)-mediated anti-SN2′ allylic substitution reaction developed in the Knochel laboratory was used to generate the sole quaternary stereogenic center in G.