Synfacts 2007(7): 0750-0750  
DOI: 10.1055/s-2007-968636
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Pd-Catalyzed Dehalogenation of Aryl Halides and α-Haloketones

Contributor(s): Paul Knochel, Andrei Gavryushin
J. Chen, Y. Zhang, L. Yang, X. Zhang, J. Liu, L. Li, H. Zhang*
Yunnan University, P. R. of China
Further Information

Publication History

Publication Date:
22 June 2007 (online)

Significance

Dehalogenation is an important process in organic chemistry, and a large number of dehalogenation methods have already been developed. The authors report herein a new mild procedure for the removal of a halogen atom (I, Br) from (hetero)arenes and α-haloketones. The conditions are compatible with a vast majority of functional groups, and the protocol is quite simple. The product yields are usually nearly quantitative. Chlorine can also be removed from activated substrates using this method.