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Synfacts 2007(7): 0769-0769  
DOI: 10.1055/s-2007-968701
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York

Polymer-Supported Dendritic Phosphine Ligands

Contributor(s): Yasuhiro Uozumi, Hiroe Takenaka
A. Dahan, M. Portnoy*
Tel Aviv University, Israel
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Publication History

Publication Date:
22 June 2007 (online)

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Significance

A series of polymer-supported dendritic phosphine ligands G1-3(X)TPP was prepared. Thus, for example, hydromethylpolystyrene was coupled with hydroxyisophthalate under Mitsunobu conditions and the resulting polymeric phthalate was reduced to give G1(O)OH. Through similar condensation-reduction sequence(s), G2 and G3(O)OH were obtained. Triphenylphosphino (TPP) groups were introduced via ester condensation of Gn(O)OH with diphenylphosphino­benzoic acid to give Gn(O)TPP. Gn(N)TPP and Gn(S)TPP were also prepared starting with bromomethyl­polystyrene.