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Synfacts 2007(8): 0889-0889  
DOI: 10.1055/s-2007-968807
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York

Xerogel-Supported Alcohol Dehydrogenase for Asymmetric Reduction

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada
M. M. Musa, K. I. Ziegelmann-Fjeld, C. Vieille, J. G. Zeikus, R. S. Phillips*
University of Georgia, Athens and Michigan State University, East Lansing, USA
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Publication History

Publication Date:
24 July 2007 (online)

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Significance

A sol-gel-encapsulated alcohol dehydrogenase (W110A TeSADH) was used for enantioselective reduction of hydrophobic ketones in organic solvents. Thus, the reaction of ali­phatic ketones was performed with xerogel-encapsulated W110A TeSADH/NADH+ in 2-propanol and hexane to give the corresponding S-secondary alcohols in 61-99% yield with 69-99% ee (6 examples). The authors mentioned that this is the first report of a preparative scale asymmetric reduction by a xerogel-encapsulated ADH in pure organic solvent media.