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Synfacts 2007(9): 0897-0897  
DOI: 10.1055/s-2007-968840
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (-)-Calycanthine and(+)-Chimonanthine

Contributor(s): Philip Kocienski
M. Movassaghi*, M. A. Schmidt
Massachusetts Institute of Technology, Cambridge, USA
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Publication History

Publication Date:
23 August 2007 (online)

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Significance

A remarkably short asymmetric synthesis of three dimeric indole alkaloids is described, in which the sterically demanding vicinal quaternary stereogenic centers in intermediate D are constructed via a reductive Co(I)-promoted dimeri­zation of the radical C.