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Synfacts 2007(10): 1088-1088  
DOI: 10.1055/s-2007-968940
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Highly Diastereoselective Formation of tert-Homopropargyl Alcohols

Contributor(s): Paul Knochel, Tobias Thaler
T. Takeda*, M. Ando, T. Sugita, A. Tsubouchi
Tokyo University of Agriculture and Technology, Japan
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Publication History

Publication Date:
07 November 2007 (online)

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Significance

This novel three-component reaction is quite remarkable especially concerning its diastereoselectivity. Tertiary alcohols resulting from the reaction of the organotitanium intermediate and a ketone are obtained with much higher selectivities than secondary alcohols.