Synfacts 2007(10): 1089-1089  
DOI: 10.1055/s-2007-968941
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Et2Zn-Catalyzed Intramolecular Hydroamination

Contributor(s): Paul Knochel, Tobias Thaler
Y. Yin, W. Ma, Z. Chai, G. Zhao*
Shanghai Institute of Organic Chemistry, P. R. of China
Further Information

Publication History

Publication Date:
07 November 2007 (online)

Significance

Intramolecular hydroamination reactions can be mediated by Et2Zn, as shown by M. Nakamura et al. (see comment section). Catalytic amounts of Et2Zn are sufficient for the synthesis of indoles. Sensitive functionalities are tolerated. Therefore, the method is applicable to a broad range of substrates. Et2Zn was also applied in the cyclization of alkynylamines. With terminal alkynes only 5-endo-dig ring closure is observed. Tandem cyclization and nucleophilic addition can be achieved by using an excess of Et2Zn.