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Synfacts 2007(10): 1018-1018  
DOI: 10.1055/s-2007-968948
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (+)-Ottelione A

Contributor(s): Philip Kocienski, Stewart Eccles
D. L. J. Clive*, D. Liu
University of Alberta, Edmonton, Canada
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Publication History

Publication Date:
07 November 2007 (online)

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Significance

Ottelione A is an excellent inhibitor of several cancer cell lines and it also inhibits tubulin polymerization. This synthesis utilizes a cyclo­propane ring to first control the stereo­chemistry during the appendage of the benzylic side chain (B to C) and then to ensure stereo­specific construction of a vinyl group (C to D).