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Synfacts 2007(11): 1198-1198
DOI: 10.1055/s-2007-991227
DOI: 10.1055/s-2007-991227
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York
Isopropoxide Protection of Aryl Boronates in the Metal-Halogen Exchange
Q. Jiang, M. Ryan, P. Zhichkin*
AMRI, Albany, USA
Further Information
Publication History
Publication Date:
23 October 2007 (online)
Significance
An in situ isopropoxide protection of pinacolyl borates is reported in this article. The isopropoxide shields the borate moiety from nucleophilic attacks of aggressive organolithium reagents. Thus, halogen-lithium exchange can be performed on these substrates leading to functionalized aryl and heteroaryl boronates.