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Synfacts 2007(11): 1194-1194  
DOI: 10.1055/s-2007-991238
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Palladium-Catalyzed Borylation and Homocoupling of Aryl Chlorides

Contributor(s): Paul Knochel, Andrei Gavryushin
K. L. Billingsley, T. E. Barder, S. L. Buchwald*
Massachusetts Institute of Technology, Cambridge, USA
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Publication History

Publication Date:
23 October 2007 (online)

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Significance

The group of Buchwald developed an extremely efficient class of ligands for the Pd-catalyzed coupling reactions. They are also suitable for the conversion of a broad variety of aryl chlorides into the corresponding boronic esters. For the first time, the formation of biaryls can be performed in one pot starting from two different aryl or hetaryl chlorides, including the electron-rich and sterically hindered ones. Catalyst loadings as low as 0.05 mol% are sufficient.