Asymmetric Nickel-Catalyzed Fluorination of Aryl Acetic Acid Derivatives

Significance

The asymmetric fluorination of β-keto carbonyl compounds has attracted interest due to the enhanced pharmaceutical activity of F-containing compounds. Here, the enantioselective electrophilic fluorination of aryl acetic acid derivatives is reported and can afford after cleavage of the thiooxazolidinone moiety chiral α-mono­fluorinated carboxylic acids without loss of stereo­chemical information (see reviews below).