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Synfacts 2007(11): 1163-1163  
DOI: 10.1055/s-2007-991271
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Enantioselective Nickel-Catalyzed Aldehyde-Alkyne Coupling

Contributor(s): Hisashi Yamamoto, Marina Naodovic
M. R. Chaulagain, G. J. Sormunen, J. Montgomery*
University of Michigan, USA
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Publication History

Publication Date:
23 October 2007 (online)

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Significance

The authors have previously reported the Ni-catalyzed coupling of aldehydes and alkynes with a wide scope of substrates. In this report, a novel type of chiral N-heterocyclic carbenes has been developed that provides coupling products with high enantioselectivities and excellent yields.