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Synfacts 2008(1): 0002-0002  
DOI: 10.1055/s-2007-991493
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (±)-Geigerin

Contributor(s): Philip Kocienski, Zofia Komsta
S. Carret, J.-P. Deprés*
CNRS, Grenoble, France
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Publication History

Publication Date:
18 December 2007 (online)

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Significance

Isolated from the African species of plant Geigera, geigerin is a member of the guaianolide family, a group of sesquiterpene lactones with interesting biological activities. The markworthy part of the synthesis is the three-step sequence used to construct the intermediate hydro­azulenone D.