Download PDF
Synfacts 2008(2): 0165-0165  
DOI: 10.1055/s-2007-992449
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

SimplePhos Monodentate Ligands: Synthesis and Applications

Contributor(s): Hisashi Yamamoto, Matthew B. Boxer
L. Palais, I. S. Mikhel, C. Bournaud, L. Micouin, C. A. Falciola, M. Vuagnoux-d’Augustin, S. Rosset, G. Bernardinelli, A. Alexakis*
Université de Genève, Switzerland and Université René Descartes, Paris, France
Further Information

Publication History

Publication Date:
23 January 2008 (online)

    Permissions and Reprints

Significance

The Alexakis group describes a new class of monodentate phosphorous ligands termed SimplePhos. These modular ligands are based on bisarylaminophosphines instead of the more common phosphoramidite compounds. These ligands achieved similar or better enantio­selectivities than their phosphoramidite counterparts in the copper-catalyzed conjugate addition reaction to cyclohexenones, desymmetrization of polycyclic hydrazines as well as allylic alkylation.