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Synfacts 2008(2): 0115-0115  
DOI: 10.1055/s-2007-992498
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (-)-Clavosolide B

Contributor(s): Philip Kocienski, Stewart Eccles
J. B. Son, M.-h. Hwang, W. Lee, D.-H. Lee*
Sogang University, Seoul, Korea
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Publication History

Publication Date:
23 January 2008 (online)

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Significance

Clavosolide B is a dimeric cyclopropane-containing metabolite of the sponge Myriastra clavosa. The key steps in this synthesis are the hydroxyl-directed cyclopropanation leading to A and the Yamaguchi macrolactonization to form a 16-membered lactone.