Download PDF
Synfacts 2008(2): 0117-0117  
DOI: 10.1055/s-2007-992499
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Formal Synthesis of (-)-Diazonamide A

Contributor(s): Philip Kocienski
C.-M. Cheung, F. W. Goldberg, P. Magnus*, C. J. Russell, R. Turnbull, V. Lynch
University of Texas at Austin, USA
Further Information

Publication History

Publication Date:
23 January 2008 (online)

    Permissions and Reprints

Significance

Diazonamide A, a metabolite of the ascidian Diazona angulata, displays potent in vitro activity against human colon cancer. A very easy O-aryl to C-aryl migration of O-tyrosine ethers B and C was used to generate the C10 quaternary stereogenic center in D and E.