Download PDF
Synfacts 2008(2): 0213-0213  
DOI: 10.1055/s-2007-992517
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York

Morita-Baylis-Hillman Reaction Catalyzed by MNP-Supported Quinuclidine

Contributor(s): Yasuhiro Uozumi, Yohei Oe
S. Luo*, X. Zheng, H. Xu, X. Mi, L. Zhang, J.-P. Cheng*
Beijing National Laboratory for Molecular Sciences and Nankai University, Tianjin, P. R. of China
Further Information

Publication History

Publication Date:
23 January 2008 (online)

    Permissions and Reprints

Significance

A magnetic nanoparticle (MNP)-supported quinuclidine catalyst for the Morita-Baylis-Hillman (MBH) reactions was described. Thus, MNP-supported quinuclidine 2 was prepared by treatment of triethoxysilane 1 with polyvinylpyrrolidone-protected MNP in refluxing toluene (eq. 1). The MBH reactions of acrylates or acrylonitrile 3 with aldehydes 4 were performed in the presence of 2 in catalytic amounts to give the corresponding adducts 5 in 62-99% yield (eq. 2).