ABSTRACT
Congenital hypoprothrombinemias are very rare, inherited disorders in which factor
II (prothrombin) levels and/or activity are extremely low or absent. We report eight
pregnancies in a patient with this disorder. Obstetric complications attributed to
the coagulation disturbance included first-trimester bleeding in each pregnancy, miscarriage
in four of the pregnancies, spontaneous maternal subarachnoid hemorrhage in one, and
postpartum hemorrhage in one of four term pregnancies despite administration of clotting
factor concentrate. The management of pregnancy in congenital hypoprothrombinemia,
and issues of coagulation factor replacement, are discussed.
Keywords
Pregnancy - coagulopathy - hypoprothrombinemia - dysprothrombinemia - prothrombin
