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Am J Perinatol 1995; 12(3): 205-207
DOI: 10.1055/s-2007-994453
ORIGINAL ARTICLE

© 1995 by Thieme Medical Publishers, Inc.

Does Preeclamptic Pregnancy Increase Fetal-Maternal Hemorrhage?

Chaur-Dong Hsu, Kristen Smith, Shih-Fen Hong, Timothy R.B. Johnson, Yvonne Gollin, Daniel W. Chan
  • Division of Maternal-Fetal Medicine, Departments of Gynecology and Obstetrics, and Division of Clinical Chemistry, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Division of Maternal-Fetal Medicine, Departments of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut
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Publication Date:
04 March 2008 (online)

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ABSTRACT

Since pathologic changes of the placenta have been found in preeclamptic pregnancies, a relationship between fetal-maternal hemorrhage and preeclampsia was investigated. Sixty-two women with singleton pregnancies in the third trimester were studied. Thirty-one of these women with preeclampsia were matched with 31 normotensive healthy pregnant women. Maternal serum levels of α-fetoprotein (MSAFP) and Kleihauer-Betke (KB) test were determined to reflect the degree of fetal-maternal hemorrhage. There were no significant differences in MSAFP levels, MSAFP to creatinine ratio, or the appearance of fetal cells as measured by the KB test between preeclamptic pregnancies and matched controls. Our data do not suggest that fetal-maternal hemorrhage is increased in pregnant women with preeclampsia.

Keywords

Preeclampsia - fetal-maternal hemorrhage - pregnancy