Isoimmunization in Pregnancy to Gerbich Antigen

David A. Sacks; Cage S. Johnson; Lawrence D. Platt

doi:10.1055/s-2007-999950

American Journal of Perinatology, Table of Contents

Am J Perinatol 1985; 2(3): 208-210
DOI: 10.1055/s-2007-999950

ORIGINAL ARTICLE

Isoimmunization in Pregnancy to Gerbich Antigen

David A. Sacks¹ , Cage S. Johnson² , Lawrence D. Platt³

¹Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Kaiser Permanente Medical Center, Bellflower, California
²Division of Hematology, Department of Medicine, University of Southern California School of Medicine, Los Angeles, California
³Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Southern California School of Medicine and Women's Hospital, Los Angeles County/USC Medical Center, Los Angeles, California

Abstract

ABSTRACT

A case of hemolytic disease of the newborn due to Gerbich, a public antigen, is presented. The antibody which was IgGI reacted in vitro with mononuclear phagocytes. Serial sonographic and amniotic fluid examinations were followed and a mildly jaundiced neonate was delivered. Further investigation may establish a relationship between severity of disease and IgG subclasses, a mononuclear phagocyte assay, and sonographic measurements. Sources of compatible blood for possible maternal, fetal, or neonatal transfusion include blood bank rare donor files, relatives, and autologous donation.

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