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Synfacts 2008(4): 0376-0376  
DOI: 10.1055/s-2008-1042792
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Catalytic Enantioselective Hydrophosphonylation of Aldehydes

Contributor(s): Mark Lautens, Valentina Aureggi
X. Zhou, X. Liu, X. Yang, D. Shang, J. Xin, X. Feng*
Sichuan University, Chengdu, P. R. of China
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Publication History

Publication Date:
19 March 2008 (online)

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Significance

Chiral α-hydroxyphosphonates are interesting intermediates in medicinal chemistry. The authors report the development of a tridentate Schiff base aluminum(III) complex for an efficient asymmetric hydrophosphonylation of aldehydes. The corresponding products are obtained in good yields and good to excellent enantioselectivities (up to 97% ee).