Rhodium(I)-Catalyzed Stereoselective Synthesis of Z-Enamines

Significance

Reported here is one of the first truly efficient protocols for highly stereoselective synthesis of Z-enamines. The methodology described provides access to kinetically favored diastereo­mers of enamines that were practically inaccessible so far. One of the most important contributions of this report is the introduction of a novel mechanistic scheme that involves intermediate metallacycles.