Heck Reaction with Silica Gel Supported Palladium Nanoparticles

Significance

Phosphine-free perfluoro-tagged palladium nanoparticles (Pd-1), which were obtained by reduction of PdCl₂ with methanol at 60 °C in the presence of NaCl and compound 1, were immobilized on fluorous silica gel (FSG) by addition of FSG to a perfluorooctane solution of Pd-1. The nano composite Pd-1/FSG (0.1 mol% Pd) catalyzed the Heck reaction of various aryl iodides 2 with methyl acrylate at 100 °C to give the corresponding methyl cinnamates in 74-98% yield (10 examples). The catalyst was recovered by filtration and reused 14 times without loss of catalytic activity.