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Synfacts 2008(5): 0507-0507
DOI: 10.1055/s-2008-1072645
DOI: 10.1055/s-2008-1072645
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Rhodium-Catalyzed Desymmetrization of Diazabicycles with Chemodivergence
F. Menard, M. Lautens*
University of Toronto, Canada
Further Information
Publication History
Publication Date:
23 April 2008 (online)
Significance
This rhodium-catalyzed desymmetrization reaction can provide either ring-opening products or reductive arylation products with excellent enantioselectivities, and the chemoselectivity can be finely controlled by the solvent and water amount used. The nitrogen-containing enantiopure products are potentially useful building blocks for natural products and pharmaceutical syntheses.