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Synfacts 2008(5): 0445-0445  
DOI: 10.1055/s-2008-1072702
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Norbadione A

Contributor(s): Philip Kocienski
Y. Bourdreaux, S. Nowaczyk, C. Billaud, A. Mallinger, C. Willis, M. Desage-El Murr, L. Toupet, C. Lion, T. Le Gall*, C. Mioskowski*
CEA, Gif-sur-Yvette, Université de Rennes and Université de Paris, France
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Publication History

Publication Date:
23 April 2008 (online)

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Significance

Norbadione A is a mushroom pigment and an antioxidant. Following the Chernobyl disaster it was found that norbadione A forms complexes with cesium 137 causing its retention and concentration in edible mushrooms (W. Steglich Angew. Chem. Int. Ed. 1989, 28, 453). The synthesis depicted is based on the use of a double Suzuki-Miyaura coupling to join the the pulvinic acid derivative I to the naphtholactone H.