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Synfacts 2008(8): 0788-0788
DOI: 10.1055/s-2008-1077895
DOI: 10.1055/s-2008-1077895
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Aigialomycin D
C. C. Chrovian, B. Knapp-Reed, J. Montgomery*
University of Michigan, Ann ARbor, USA
Further Information
Publication History
Publication Date:
23 July 2008 (online)
Significance
Aigialomycin D was isolated from the marine mangrove fungus Aigialus parvus. It exhibits activity as an antimalarial and cytotoxic agent. This synthesis of aigialomycin D utilizes a nickel(0)-catalyzed ynal coupling to form the macrocycle.