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Synfacts 2008(8): 0831-0831  
DOI: 10.1055/s-2008-1077906
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Ru-Catalyzed Carbonyl Allylations from Alcohols or Aldehydes

Contributor(s): Mark Lautens, Praew Thansandote
F. Shibahara, J. F. Bower, M. J. Krische*
University of Texas at Austin, USA
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Publication History

Publication Date:
23 July 2008 (online)

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Significance

The authors describe a C-C coupling between acyclic 1,3-dienes and aryl alcohols or aldehydes under Ru-catalyzed transfer hydrogenation conditions using alcohols as terminal reductants. Selectivity for the branched product is observed in all cases and good yields are reported for a large scope of substrates. The present report provides a good alternative to carbonyl additions using preformed organometallic reagents.