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Synfacts 2008(8): 0795-0795
DOI: 10.1055/s-2008-1078527
DOI: 10.1055/s-2008-1078527
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of (+)-Lactacystin
C. J. Hayes*, A. E. Sherlock, M. P. Green, C. Wilson, A. J. Blake, M. D. Selby, J. C. Prodger
University of Nottingham, Pfitzer Global Research and Development, Kent and GlaxoSmithKline Medicines Research Centre, Stevenage, UK
Further Information
Publication History
Publication Date:
23 July 2008 (online)
Significance
A formal synthesis of (+)-lactacystin and its biological precursor omuralide was reported by the same group earlier. Herein a scalable approach to H is reported as well as a new endgame strategy. Unprotected H is an intermediate in a previous synthesis (H. Uno, J. E. Baldwin, A. T. Russell J. Am. Chem. Soc. 1994, 116, 2139).