Synfacts
Issue 05 · May 2023
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SYNFORM
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Synthesis of Natural Products
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0427
Synthesis of (±)-Vilmoraconitine
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0428
Synthesis of (+)-Kopsaporine
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0429
Total Synthesis of (+)-Isoneoamphilectane
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0430
Synthesis of (+)-Epiibogamine
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0431
Total Synthesis of (+)-Zizaene
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0432
Total Synthesis of (+)-Stephadiamine
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0433
Synthesis of (±)-Ingenol
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Synthesis of Heterocycles
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0435
NHC-Mediated Synthesis of γ-Lactams
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0436
Organocatalytic Cloke–Wilson Rearrangement to Access Multi-Substituted Furans
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0437
Copper-Catalyzed Benzylic sp
3
C–H Oxidative Annulation of Ketones and Amines
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0438
Robust Synthesis of Functionalized Bicyclic Heteroaromatic Sulfonyl Fluorides
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0439
Ruthenium-Catalyzed Synthesis of Piperazines and Diazepanes
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0440
Zn-Mediated Synthesis of Pyridines from Alcohols
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0441
Practical Arynes from Unfunctionalized Arenes
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0442
Versatile Synthesis of 4-Iodopyrrole-2-carbaldehydes
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0443
Improved Synthesis of the DLK Inhibitor GDC-0134
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0444
Savie: A Biodegradable ‘Drop-In’ Surfactant Replacement for TPGS-750-M
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0445
Transformations of Aliphatic Amines and Anilines into Diverse Functionalities
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0446
One-Pot Synthesis of N-Functionalized Indoles through a Three-Step Tandem Process
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0447
Aerobic Oxidative Cycloaddition Reactions for Pyrazole Synthesis
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Synthesis of Materials and Unnatural Products
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0449
From Biphenyl Triflate to Fluorene
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0450
Remote C–H Functionalization on Stacked Aromatics
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0451
Expanded [23]-Helicene
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0452
Hypervalent Iodine Put to Use
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0453
Versatile Syntheses of Crowded Trisphosphines
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0454
A New T-Type Molecular Photoswitch
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0455
Light-Induced Radical-Mediated Minisci Alkylation
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0456
Seven- to Eight-Membered Polyene Ring Expansion
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0457
The Role of Counteranion in Rhodium Catalysis
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0458
One-Pot Synthesis of Degradable Block Copolymers
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0459
Radical-Polymerizable Masked Vinylboronic Acids
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0460
Room-Temperature C–N Coupling
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Metals in Synthesis
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0461
Cutting Me Off: Selective N-Demethylation of Trialkylamines Using C(sp
2
)–Bromides as HAT Reagents
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0462
Synthesis of C-4 Substituted Indoles via Pd-Catalyzed Decarbonylative Cyclization
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0463
Highly
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-Selective Hydrogenation of Alkynes Using Chromium and Cyclic Carbene Ligands
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0464
Copper-Catalyzed Carbophosphonylation of Styrenes
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0465
Pt/Zn-Catalyzed Diborylation of Propargylic Amines
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0466
Allylic C(sp
3
)–H Functionalization of Propylene and Alkenes Catalyzed by a Cationic Iron(II) Complex
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0467
Nickel/Photoredox-Catalyzed C(sp
3
)–H Arylation in the γ-Position of Sulfamate Esters and Amides
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0468
Mono-
ortho
-Alkylation of Meta-Substituted Iodoarenes Using a Cycloolefin Ligand in a Catellani-Type Reaction
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0469
Palladium-Catalyzed Rearrangement of 3-Arylcyclobutanones to 1-Indanones
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0470
Synthesis of Skipped Trienes via Ni-Catalyzed Bis-Allylation of Alkynes
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0471
Rhodium-Catalyzed [4+2+1] Annulation Harnessing the Strain Release of a Methylenecyclopropyl Group
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0472
Samarium(II) Iodide-Catalyzed Formal [2π+2σ] Cycloaddition of Bicyclo[1.1.0]butyl Ketones and Alkenes
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0473
Dearomative Carboxylation of (Hetero)Arenes with Cesium Formate under Dual Photoredox/HAT Catalysis
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0474
Desulfonylative Cross-Electrophile Coupling of Aryl Sulfones and Aryl Bromides under Nickel Catalysis
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0475
Nickel-Catalyzed Carbonylation of Alkyl Halides to Acyl Chlorides under Blue Light Irradiation
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0476
Pd-Catalyzed Arylation of Furans and Pyrroles Facilitated by Remote Carbonyl Groups
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0477
Synthesis of Functionalized Nitriles using a Nickel-Catalyzed Substitution of Allylic Alcohols
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0478
Copper-Catalyzed Enantioconvergent C(sp
3
)–P Cross-Coupling of Secondary Benzyl and Propargyl Bromides
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0479
Installation of the Magic Methyl Group onto Heterocycles by Dual Decatungstate Photo-/Nickel Catalysis
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0480
Palladium-Catalyzed Enantioselective Synthesis of α-Alkenyl-Substituted 2,3-Dihydrobenzofurans
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0481
Synthesis of Thioethers via Ni-Catalyzed Cross-Coupling of Alkyl Thiols with Aryl or Alkenyl Triflates
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0482
Enantioselective Synthesis of Allylsilanes by Nickel-Catalyzed Hydrosilylation of 1,1-Disubstituted Allenes
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0483
Nickel-Catalyzed Synthesis of Enantioenriched Tertiary Alcohols via DyKAT Processes
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0484
Ligand-Controlled Stereodivergent Allylic C(sp
3
)–H Arylation under Dual Photoredox/Nickel Catalysis
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0485
Copper-Catalyzed Enantioselective Dienolate Additions to Aldehydes
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0486
Palladium-Catalyzed [4+2] Annulation to Access [6.7]-Fused
N
-Heterocycles
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0487
The Fürstner Indole Synthesis: Titanium-Catalyzed Intramolecular McMurry-Type Carbonyl Coupling
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Polymer-Supported Synthesis
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0489
Photocatalytic Dehydrogenative Amination of Cyclohexanones
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0490
Hydrogenation of Benzofurans, Indoles, and Benzothiophenes by Co/Co
3
O
4
Core-Shell NPs on Silica
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0491
Oxidative Transformation of Silanes Using a Cobalt Catalyst, Supported on N-Doped Porous Carbon
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0492
Asymmetric Michael Addition Catalyzed by Chiral-Diamine-Modified Ni Nanoparticles on SiO
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0493
Aziridination and Oxyamination of Styrenes with a Single-Atomic Cobalt Catalyst
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0494
Oxidative Coupling of Phenols and Alkenylphenols with TiO
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under Visible Light Irradiation
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0495
Exhaustive Hydrogenation of Esters and Carboxylic Acids to Alkanes with a Heterogeneous Pt Catalyst
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0496
Semihydrogenation of Alkynes Promoted by a 2D Palladium Metallenes Loaded on Niobium Carbide
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0497
Enantioselective Synthesis of Quaternary Tryptolines by a Polystyrene-Supported Phosphoric-Acid Catalyst
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0498
Nanocrystal Facet Effects of Ceria in Pd/CeO
2
Catalysts for Oxidation of Benzyl Alcohols
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0499
β-Selective Furanosylation of α-Furanosyl Fluoride Donors Inside Resorcin[4]arene Supramolecular Capsule
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Organo- and Biocatalysis
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0501
Visible-Light Photocatalysis Enables Anti-Markovnikov Hydrofunctionalization of α-Olefins
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0502
Breaking Symmetry: Dynamic Kinetic Resolution Enables Organocatalytic Synthesis of Dual-Axial Compounds
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0503
Transition-Metal-Mimicking Behavior of New Cationic Constrained Phosphine Species
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0504
Chiral Phosphoric Acid Permits Desymmetrizing Hydrolysis of Oxidatively Generated S(VI) Dichlorides
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0505
Peptide Catalysis Permits Asymmetric Conjugate Addition of Aldehydes to α-Substituted Vinyl Triflones
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0506
Aldol-Type Reaction of α,α-Difluoromethyl Ketones Catalyzed by an Organosuperbase
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0507
Dual-Role Disulfide-Catalyzed Intramolecular Hydroamination through N–H Activation
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0508
Imine Reductase for the Synthesis of Pharmaceutically Relevant Amines
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Innovative Drug Discovery and Development
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0509
Bicycloheptanes as
meta
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0510
Utilizing Kinetic Modeling for the Conservative Prediction of Dialkyl-
N
-Nitrosamine Formation
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0511
Synthesis of Novel (±)-Lysergic Acid Derivative 12-Chlorolysergic Acid
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0512
Aptamer-LYTACs Access Tissue-specific Targeted Degradation
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0513
Chemoenzymatic Synthesis of Cepafungin I and Its Analogs
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0514
Enantioselective Synthesis of Drug Precursors by Photo-HAT and Facially Selective Radical Capture
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0515
Continuous-Flow Process For Safe Formation and Direct Use of Aryldiazoacetate in Cyclopropanation
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0516
Introduction of a Potent and Selective JNK2 Inhibitor
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0517
Shining Light on Aryl Nitrenes
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0518
General BCP-Wing C–H Activation and Rapid Access to Diverse Bridge-Substituted Arene Bioisosteres
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0519
Ultralow Band Gap Conjugated Polymers Serve As Photothermal Therapeutic Agents
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0520
Synthesis Confirming Structure: The Lobelia Alkaloids
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Peptide Chemistry
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0521
Ir-Catalyzed Enantio- and Diastereoselective Synthesis of 3-Substituted Proline Derivatives
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0522
Iodide-Mediated Amidation Reaction under Electrochemical Conditions
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0523
Photochemical Synthesis of Unnatural Amino Acids through CF
3
Radical Addition to Michael Acceptors
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0524
Synthesis of Quaternary-Substituted α-Amino γ‑Butyrolactams
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0525
Pd and Cu Synergistic Catalysis for the Synthesis of α,α-Disubstituted Amino Acids
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0526
Synthesis of Fluorinated Non-Canonical Peptides from α-Fluorinated Carboxylic Acid
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0527
β,γ,δ,ε-Amino Acid Synthesis by Photocatalytic Carboxylation with CO
2
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0528
Arylation of Short Peptides Using a Palladium Catalyst
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0529
Deprotection of 2,2-Dimethyl-2-(
o
-nitrophenyl)acetyl (DMNA) Group in Amino Acids and Peptides
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Flow Chemistry
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0531
Effects of Different Substituents on the Regioselectivity of a Photocascade Reaction in Continuous Flow
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Erratum
0532
Erratum: Cu-Catalyzed Hydrogermylation of Dehydro Amino Acids
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