DOI : 10.1055/s-00000094

Zeitschrift für Gastroenterologie

Issue 01 · Volume 63 · January 2025 DOI: 10.1055/s-015-60935


41. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber
Klinikum rechts der Isar der Technischen Universität München, 14.–15.02.2025

Tagungspräsident:
Prof. Dr. Percy A. Knolle
Abstracts (HTML) Abstracts (PDF) List of Authors
P3.01
Li, Siyuan; Zheng, Chaowen; Chen, Cheng; Lyu, Huanran; Mueller, Johannes; Hammad, Seddik; Dooley, Steven; Mueller, Sebastian: Stabilin1 mediates ingestion of oxidized erythrocytes by LSECs (efferocytosis)
P3.02
Laevens, Benjamin; Jakhar, Niharika; Koop, Paul-Henry; Liu, Yuanyuan; Raju, Thriveni B.; van Haag, Felix; Schneider, Kai Markus; Loomba, Rohit; Victoria Schneider, Carolin: Live(r) and Let Live: Combining AI and Citizen Science in Hepatology
P3.03
Raptis, Anastasia Artemis; Jakhar, Niharika; Clusmann, Jan; van Haag, Felix; Canbay, Ali; Seibel, Tobias; Schneider, Kai Markus; Schneider, Carolin Victoria: 30% with hepatic steatosis – but who is at risk? Defining Risk Factors for major liver-related Outcomes in patients with Metabolic Dysfunction- Associated Steatotic Liver Disease (MASLD)
P3.04
Herzberger, Lisa; Griesser, Eva; Dreher, Christina; Cantow, Chris; Müller-Vieira, Ursula; Ehnert, Sabrina; Nüssler, Andreas: In vitro characterization of the drug metabolizing capacity of hepatocytes from MASH livers and development of a PK model for MASH patients
P3.05
Li, Gang; Staffer, Simone; Tuma-Kellner, Sabine; Altamura, Sandro; Muckenthaler, Martina; Merle, Uta; Chamulitrat, Walee: Myeloid- and hepatocyte-specific deletion of group VIA calcium-independent phospholipase A2 leads to opposing phenotypes during HFD-induced NASH
P3.06
John, Katharina; Franck, Martin; Rau, Monika; Geier, Andreas; Sowa, Jan-Peter; Schattenberg, Jörn; Wedemeyer, Heiner; Schulze-Osthoff, Klaus; Bantel, Heike: Comparison of histological and non-invasive assessment of significant fibrosis in a multicenter cohort of MASLD patients
P3.07
Bergmann, Christian; Ott, Fritzi; Körner, Christiane; Carrillo, Sebastian Lara; Klingmüller, Ursula; Berg, Thomas; Matz-Soja, Madlen: The role of sex-specific mitochondrial changes in the pathogenesis of fatty liver disease
P3.08
Schattenberg, Jörn; Taub, Rebecca; Labriola, Dominic; Alkhouri, Naim; Noureddin, Mazen; King, Thomas: Liver enzymes reductions from baseline over time in resmetirom treated patients in a Phase 3 study, MAESTRO-NASH
P3.09
Ott, Fritzi; Körner, Christiane; Bergmann, Christian; Schröder, Helen; Friebel, Adrian; Zhipeng, Deng; Hoehme, Stefan; Carrillo, Sebastian Lara; Klingmüller, Ursula; Damm, Georg; Seehofer, Daniel; Brosch, Mario; Hampe, Jochen; Berg, Thomas; Matz-Soja, Madlen: Dynamics of disease progression and regeneration in a multiscale liver model
P3.10
Chen, Yazhou; Laevens, Benjamin; Lemainque, Teresa; Müller-Franzes, Gustav Anton; Seibel, Tobias; Dlugosch, Carola; Clusmann, Jan; Koop, Paul-Henry; Gong, Rongpeng; Schophaus, Simon; Raju, Thriveni B.; Jakhar, Niharika; Raptis, Anastasia Artemis; van Haag, Felix; Liu, Yuanyuan; Cao, Feng; Loomba, Rohit; Valenti, Luca; Kather, Jakob Nikolas; Brinker, Titus J.; Herzog, Moritz; Costa, Ivan G.; Hernando, Diego; Schneider, Kai Markus; Truhn, Daniel; Schneider, Carolin Victoria: Deep learning can predict PNPLA3 I148M homozygous carriers in SLD patients based on MRIs from UK Biobank
P3.11
Koehler, Jan Philipp; Yaqubi, Kaneschka; von Gradowski, Kathrin; May, Petra; Luedde, Tom; vom Dahl, Stephan: First successful pregnancies in patients with cerebrotendinous xanthomatosis treated with chenodeoxycholic acid in Germany
P3.12
Seibel, Tobias; Koop, Paul-Henry; Jakhar, Niharika; Laevens, Benjamin; Schneider, Kai Markus; Schneider, Carolin Victoria: Machine learning can predict advanced but not early liver disease on brain MRI
P3.13
Jegodzinski, Lina; Clermont, Christian; Jessen, Christian; Castven, Darko; Sayk, Friedhelm; Marquardt, Jens: Elevated uric acid levels are associated with an increased risk of fibrosis in MASLD
P3.14
Fatima, Hooriya; Maqbool, Humayoun Huma; Ahmad, Husna; Sheikh, Nadeem: Molecular Insights: Gene Expression in HCC and Testicular Cancer among ALD Patients
P3.15
Angendohr, Carolin; Koppe, Christiane; Schneider, Anne Theres; Keysberg, Leonie; Singer, Michael; Dille, Matthias; Bode, Johannes; Doll, Sebastian; Conrad, Marcus; Vucur, Mihael; Luedde, Tom: The ferroptosis mediator ACSL4 fails to prevent disease progression in mouse models of MASLD
P3.16
Seibel, Tobias; Koop, Paul-Henry; Schäfer, Jakob; Chaghaneh, Omid; Gabriel, Tina; Schneider, Kai Markus; Hampe, Jochen; Fettweis, Gerhard Paul; Schneider, Carolin Victoria; Herzog, Moritz: Predicting Controlled Attenuation Parameter and Elastographic Modulus from Handheld Ultrasound Device Data using Machine Learning
P3.17
Brisbois, Malvina; Lambert, Irina; Oezen-Karatayli, Senem; Weber, Susanne; Krawczyk, Marcin Jan: Do genetic variants modulate liver injury in patients with diabetes mellitus? – results of a prospective, single center study
P3.18
Raju, Thriveni B.; Beckmann, Alina V.; Haque, Madhuri; Treichel, Nicole S.; Chen, Yazhou; Laevens, Benjamin; Schneider, Kai Markus; Schorning, Kirsten; Schneider, Carolin V.: Machine learning identifies microbiome associations with MASLD biomarkers
P3.19
Liu, Yuanyuan; Cao, Feng; Seibel, Tobias; Jakhar, Niharika; Chen, Yazhou; Raju, Thriveni B.; Schneider, Carolin Victoria; Schneider, Kai Markus: Impact of Diabetes and its management on MASLD risk
P3.20
Kupke, Paul; Bitterer, Florian; Adenugba, Akinbami; Evert, Katja; Glehr, Gunther; Riquelme, Paloma; Scheibert, Lena; Preverin, Giulia; Böhm, Christina; Hornung, Matthias; Schlitt, Hans-Jürgen; Wenzel, Jürgen J.; Geissler, Edward K.; Safinia, Niloufar; Hutchinson, James; Werner, Jens: Soluble CD46 as a diagnostic biomarker for steatotic liver disease
P3.21
Vahrenbrink, Madita; Kuipers, Sonja; Kuna, Manuela; Schjeide, Brit-Maren; Dittrich, Stephan; Püschel, Gerhard; Henkel-Oberländer, Janin: Dynamic changes in macrophage populations in MASLD and its influence on prostaglandin E2-mediated signaling
P3.22
Bogovic, Niklas; Keller, Marie; Schneider, Lydia; Junger, Henrik; Schlitt, Hans-Jürgen; Eggenhofer, Elke: Unraveling MASH: Kupffer Cell-Driven Inflammation and Fibrosis within Hepatic Spheroids as a 3D Disease Model
P3.23
Bogovic, Niklas; Schneider, Lydia; Junger, Henrik; Schlitt, Hans-Jürgen; Eggenhofer, Elke: Targeting ICAM and VCAM in MASH: The Role of Nintedanib and Dasatinib in Reducing Inflammation, Fibrosis, and Growth Factor Expression in Liver Spheroids
P3.24
Rudolph, Lenhard: Vitamin A metabolism in MASLD development during mouse aging
P3.25
Koehler, Jan Philipp; Yaqubi, Kaneschka; Mengel, Eugen; von Gradowski, Kathrin; May, Petra; Thimm, Eva; Mayatepek, Ertan; Luedde, Tom; vom Dahl, Stephan: ASMD (acid sphingomyelinase deficiency), formerly Morbus Niemann-Pick type A/B: four adult cases with idiopathic hepatosplenomegaly and first results from enzyme replacement therapy (ERT) with olipudase alfa
P3.26
Kowalczyk, Manuela; Flamant, Frédéric; Gauthier, Karine; Lange, Christian M.; Moeller, Lars C.; Zwanziger, Denise: Abrogation of Hepatic TRβ Action Protects the Liver from Acute Liver Injury
P3.27
Kowalczyk, Manuela; Flamant, Frédéric; Gauthier, Karine; Lange, Christian M.; Moeller, Lars C.; Zwanziger, Denise: Absence of cholesterol gallstone formation in male C57BL/6 mice by abrogation of hepatic thyroid hormone action
P3.28
Myllys, Maiju; Hobloss, Zaynab; Schmidt, Hannah; González, Daniela; Hassan, Reham; Hendawi, Rama; Begher-Tibbe, Brigitte; Reinders, Joerg; Hofmann, Ute; Hengstler, Jan; Ghallab, Ahmed: TLR4 and CD14 as potential therapeutic targets for LPS-induced acute-on-chronic liver failure
P3.29
Schuehle, Svenja; Kotsiliti, Elena; Qiu, Mengjie; Cohen, Yotam; Deng, Sisi; Omer, Hélène; Han, Feng; Schmidt, Sabine; Zonouzi, Aysan Poursadegh; Faure-Dupuy, Suzanne; Avila, Jose Barragan; Fernández-Vaquero, Mirian; Prokosch, Sandra; Rothermel, Ulrike; Müller, Florian; Hetzer, Jenny; Heide, Danijela; Herebian, Diran; Mager, Lukas; Bucci, Daniele; Waisman, Ari; Trautwein, Christoph; Haller, Dirk; Elinav, Eran; Heikenwälder, Mathias: Antibiotic-mediated microbiota depletion limits IgA-related fibrogenesis in metabolic dysfunction-associated steatohepatitis
P3.30
Wiethoff, Hendrik; Fichtner, Alexander; Merle, Uta; Schirmacher, Peter; Longerich, Thomas: Clinical Utility of Metallothionein Immunohistochemistry (MT-IHC) for Early Tissue-based Diagnosis of Wilson Disease (WD)
P3.31
Scheibert, Lena; Glehr, Gunther; Hutchinson, James; Geissler, Edward; Kupke, Paul; Werner, Jens; Schlitt, Hans-Jürgen; Kronenberg, Katharina; Riquelme, Paloma; Zhou, Jordi Yang: Angiopoietin-1 Receptor (CD202b) Identifies IL-4-secreting Human Invariant Natural Killer Cells
P3.32
Kubitz, Phil; Dashti, Hesam; Claussnitzer, Melina; Klingenspor, Martin; Hauner, Hans; Geier, Andreas: Association of the PNPLA3 p.I148M common variant with increased resting energy expenditure in the context of cold adaptation in humans
P3.33
Gieseler, Robert; Goetze, Oliver; Kücükoglu, Özlem; Baars, Theodor; Özcürümez, Mustafa Kemal; Canbay, Ali: Towards Establishing L-Ornithine-L-Aspartate as a Potential Basic Medication for Metabolic Dysfunction-associated Steatotic Liver Disease
P3.34
Daza, Jimmy; De La Espriella, Victor; Alcazar, Milena; Chavarria, Tatiana; Restrepo, Juan Carlos; Evert, Matthias; Navas, Maria Cristina; Teufel, Andreas: Mobile Ultrasound Screening Program for MASLD in High Cardiovascular Risk Communities in Rural Colombia: Initial Results
P3.35
Sagstetter, Felicitas; Itzel, Timo; Antoni, Christoph; Klindt-Morgan, Caroline; Finze, Alida; Otto, Mirko; Reißfelder, Christoph; Ebert, Matthias; Teufel, Andreas: Health related quality of life (HRQoL) in patients Metabolic dysfunction-associated steatotic liver disease (MASLD)
P3.36
Rau, Monika; Kestel, Johanna; De Monte, Sara; Leicht, Hans Benno; Reiter, Florian Paul; Hermanns, Heike; Geier, Andreas: Long-term outcomes of Metabolic dysfunction associated steatotic liver disease (MASLD) patients in a prospective, German real-world cohort
P3.37
Rau, Monika; Buggisch, Peter; Klinker, Hartwig; Mauss, Stefan; Heyne, Renate; Simon, Karl-Georg; Berg, Thomas; Geier, Andreas; Wedemeyer, Heiner; Hupa-Breier, Katharina: Overweight, but not alcohol is associated with increased risk for advanced liver disease in patients with chronic hepatitis C infection- results from the German Hepatitis C-Registry (DHC-R)