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Drug Res (Stuttg) 2022; 72(09): 487-495
DOI: 10.1055/a-1899-8233
Review

Nrf2 Mediated Heme Oxygenase-1 Activation Contributes to Diabetic Wound Healing – an Overview

Vadivelan Ramachandran 
1   Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, The Nilgiris, Tamilnadu, India
,
Tharani Mohanasundaram
1   Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, The Nilgiris, Tamilnadu, India
,
Ruchi Tiwari
2   Pranveer Singh institute of Technology (Pharmacy), Kanpur – Agra – Delhi, NH2, Bhauti, Kanpur, Uttar Pradesh, India
,
Gaurav Tiwari
2   Pranveer Singh institute of Technology (Pharmacy), Kanpur – Agra – Delhi, NH2, Bhauti, Kanpur, Uttar Pradesh, India
,
Putta Vijayakumar
3   Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, The Nilgiris, Tamilnadu, India
,
Bhargav Bhongiri
3   Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, The Nilgiris, Tamilnadu, India
,
Rinu Mary Xavier
3   Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, The Nilgiris, Tamilnadu, India
› Author Affiliations Funding This review article did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
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Abstract

Diabetic wound healing is a complicated procedure because hyperglycemia changes the various stages of wound healing. In type 2 diabetes mellitus (T2DM), oxidative stress is proven to be a critical factor in causing non-healing wounds and aggravating the inflammatory phase, resulting in the amputation of lower limbs in T2DM patients. This makes scientists figure out how to control oxidative stress and chronic inflammation at the molecular level. Nuclear factor erythroid 2- related factor 2 (Nrf2) releases antioxidant proteins to suppress reactive oxygen species (ROS) activation and inflammation. The current review discusses the role of Nrf2 in improving diabetic wound healing by reducing the production of ROS and thus reducing oxidative stress, as well as inhibiting nuclear factor kappa B (NF-kB) dissociation and nuclear translocation, which prevents the release of inflammatory mediators and increases antioxidant protein levels, thereby improving diabetic wound healing. As a result, the researcher will be able to find a more effective diabetic wound healing therapy.

Key words

Nrf2 - anti-oxidants - ROS - diabetic wound healing - anti-inflammatory - HO-1


Publication History

Received: 01 June 2022

Accepted: 11 July 2022

Article published online:
05 August 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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