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Horm Metab Res 2023; 55(10): 684-691
DOI: 10.1055/a-2151-1538
Original Article: Endocrine Care

Thyroid-Related Hormones Changes Predict Changes in Anthropometric Measures and Incidence of Obesity in Chinese Euthyroid Persons

Ling Deng 
1   Laboratory of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China
2   Department of Health Management & Institute of Health Management, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
,
Xiaoxia Zheng
2   Department of Health Management & Institute of Health Management, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
,
Ping Shuai
2   Department of Health Management & Institute of Health Management, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
,
Xijie Yu
1   Laboratory of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China
› Author Affiliations Funding Information The 1.3.5 project for discipline of excellence, West China Hospital, Sichuan University — 2020HXFH008; ZYJC18003 National Natural Science Foundation of China — http://dx.doi.org/10.13039/501100001809; 82273294 Department of Science and Technology of Sichuan Province — http://dx.doi.org/10.13039/501100004829; 2022YFS0136 The Sichuan University — 2018SCUH0093 Chengdu Bureau of Science and Technology — 2022-YF05–01316-SN
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Abstract

The purpose of this study was to investigate the correlation of thyroid-related hormones changes within the reference range with the changes in anthropometric measures and incidence of obesity. The study included 4850 subjects with normal thyroid-related hormones at baseline and at follow-up. We evaluated the relationship of changes in thyroid-related biomarkers with anthropometric measures changes and incidence of obesity. In euthyroid persons, changes in serum thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) concentrations and FT3/FT4 ratio were independent predictors of changes in body mass index (BMI) and waist circumference (WC) in men, changes in serum FT3 and FT4 concentrations and FT3/FT4 ratio were independent predictors of changes in BMI and WC in women. Every single unit increment in ΔFT3/FT4 was accompanied by a 7.144 and 7.572 times risk of having obesity in men and women, respectively. Every single unit decrement in ΔFT4 was accompanied by a 21.0% and 26.9% lower risk of having obesity in men and women, respectively. In conclusion, in euthyroid individuals, changes in thyroid-related hormones were associated with anthropometric measures changes and incidence of obesity.

Key words

thyroid-related hormone - anthropometric measure - obesity - euthyroid person

Additional material



Publication History

Received: 06 June 2022

Accepted after revision: 09 August 2023

Accepted Manuscript online:
09 August 2023

Article published online:
09 October 2023

© 2023. Thieme. All rights reserved.

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