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Synlett
DOI: 10.1055/a-2770-5422
Letter

Preparation of Nitrones by Hydrogenation of 2-(2-Nitro-1-phenylethyl)cyclohexanones

Autoren

  • Xiaochen Li

    1   Department of Chemistry, Kobe University, Kobe, Japan

  • Aina Sakamoto

    2   Chemistry, Kobe University, Kobe, Japan

  • Rinka Aranaga

    1   Department of Chemistry, Kobe University, Kobe, Japan

  • Suguru Murakami

    1   Department of Chemistry, Kobe University, Kobe, Japan

  • Ryosuke Matsubara

    2   Chemistry, Kobe University, Kobe, Japan

  • Masahiko Hayashi

    3   Department of Chemistry, Graduate School of Science, Kobe University, Kobe, Japan

Gefördert durch: the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
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A practical and simple synthetic strategy for the synthesis of nitrones have been developed. Hydrogenation of 2-(2-nitro-1-phenylethyl)cyclohexanone by Pd/C afforded the corresponding nitrones in good to high and in high diastereoselectively. The starting materials, 2-(2-nitro-1-phenylethyl)cyclohexanones were easily prepared by the reaction of substituted cyclohexanones and nitroalkenes in the presence of 10 mol% of pyrrolidine.



Publikationsverlauf

Eingereicht: 29. September 2025

Angenommen nach Revision: 10. Dezember 2025

Accepted Manuscript online:
11. Dezember 2025

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