Semin Neurol 2011; 31(3): 286-306
DOI: 10.1055/s-0031-1287658
© Thieme Medical Publishers

Cerebrovascular Disease in Central Nervous System Infections

Felicia C. Chow1 , 2 , 3 , Christina M. Marra4 , Tracey A. Cho1 , 2 , 3
  • 1Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts
  • 2Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts
  • 3Harvard Medical School, Boston, Massachusetts
  • 4Department of Neurology, University of Washington, Seattle, Washington
Further Information

Publication History

Publication Date:
30 September 2011 (online)

ABSTRACT

Cerebrovascular disease is a complication of a variety of infections affecting the central nervous system (CNS). Infection may cause vasculitis affecting primarily the vessels at the base of the brain in the setting of meningitis; an immune-mediated parainfectious process leading to vasospasm or thrombosis; or a hypercoagulable state in combination with endothelial dysfunction resulting from activation of inflammatory and procoagulant cascades. Although systemic signs and symptoms may be present to aid in the diagnosis, cerebral infarction secondary to infection may be indistinguishable from more typical causes of stroke. Confirmation of an infectious vasculitis may also be challenging, as brain biopsy, the gold standard for diagnosis, is rarely pursued. In many CNS infections, vascular complications portend a poor prognosis as they are often associated with devastating neurologic outcomes, including death, underscoring the importance of early recognition and appropriate therapy. In this review, we address bacterial, viral, fungal, and parasitic causes of cerebrovascular disease.

REFERENCES

  • 1 Kiechl S, Egger G, Mayr M et al.. Chronic infections and the risk of carotid atherosclerosis: prospective results from a large population study.  Circulation. 2001;  103 (8) 1064-1070
  • 2 Elkind M SV, Ramakrishnan P, Moon Y P et al.. Infectious burden and risk of stroke: the northern Manhattan study.  Arch Neurol. 2010;  67 (1) 33-38
  • 3 Grau A J, Brandt T. Do multiple chronic infections increase the risk of stroke?: the infectious burden concept.  Arch Neurol. 2010;  67 (1) 16-17
  • 4 Thigpen M C, Whitney C G, Messonnier N E Emerging Infections Programs Network et al. Bacterial meningitis in the United States, 1998-2007.  N Engl J Med. 2011;  364 (21) 2016-2025
  • 5 Durand M L, Calderwood S B, Weber D J et al.. Acute bacterial meningitis in adults. A review of 493 episodes.  N Engl J Med. 1993;  328 (1) 21-28
  • 6 Kastenbauer S, Pfister H W. Pneumococcal meningitis in adults: spectrum of complications and prognostic factors in a series of 87 cases.  Brain. 2003;  126 (Pt 5) 1015-1025
  • 7 Pfister H W, Borasio G D, Dirnagl U, Bauer M, Einhäupl K M. Cerebrovascular complications of bacterial meningitis in adults.  Neurology. 1992;  42 (8) 1497-1504
  • 8 Weststrate W, Hijdra A, de Gans J. Brain infarcts in adults with bacterial meningitis.  Lancet. 1996;  347 (8998) 399
  • 9 van de Beek D, de Gans J, Tunkel A R, Wijdicks E FM. Community-acquired bacterial meningitis in adults.  N Engl J Med. 2006;  354 (1) 44-53
  • 10 van de Beek D, de Gans J, Spanjaard L, Weisfelt M, Reitsma J B, Vermeulen M. Clinical features and prognostic factors in adults with bacterial meningitis.  N Engl J Med. 2004;  351 (18) 1849-1859
  • 11 Klein M, Koedel U, Kastenbauer S et al.. Delayed cerebral thrombosis after initial good recovery from pneumococcal meningitis: past as prologue: delayed stroke as a parainfectious process of bacterial meningitis?.  Neurology. 2010;  75 (2) 193-194, author reply 193–194
  • 12 van de Beek D, Patel R, Wijdicks E FM. Meningococcal meningitis with brainstem infarction.  Arch Neurol. 2007;  64 (9) 1350-1351
  • 13 Schut E S, Brouwer M C, de Gans J, Florquin S, Troost D, van de Beek D. Delayed cerebral thrombosis after initial good recovery from pneumococcal meningitis.  Neurology. 2009;  73 (23) 1988-1995
  • 14 Levi M, van der Poll T, Büller H R. Bidirectional relation between inflammation and coagulation.  Circulation. 2004;  109 (22) 2698-2704
  • 15 Vergouwen M DI, Schut E S, Troost D, van de Beek D. Diffuse cerebral intravascular coagulation and cerebral infarction in pneumococcal meningitis.  Neurocrit Care. 2010;  13 (2) 217-227
  • 16 Klein M, Koedel U, Kastenbauer S et al.. Delayed cerebral thrombosis after initial good recovery from pneumococcal meningitis: past as prologue: delayed stroke as a parainfectious process of bacterial meningitis?.  Neurology. 2010;  75 (2) 193 author reply 193-194
  • 17 Czartoski T, Hallam D, Lacy J M, Chun M R, Becker K. Postinfectious vasculopathy with evolution to moyamoya syndrome.  J Neurol Neurosurg Psychiatry. 2005;  76 (2) 256-259
  • 18 Pugin D, Copin J C, Goodyear M C, Landis T, Gasche Y. Persisting vasculitis after pneumococcal meningitis.  Neurocrit Care. 2006;  4 (3) 237-240
  • 19 Tunkel A R, Hartman B J, Kaplan S L et al.. Practice guidelines for the management of bacterial meningitis.  Clin Infect Dis. 2004;  39 (9) 1267-1284
  • 20 de Gans J, van de Beek D. European Dexamethasone in Adulthood Bacterial Meningitis Study Investigators . Dexamethasone in adults with bacterial meningitis.  N Engl J Med. 2002;  347 (20) 1549-1556
  • 21 van de Beek D, Farrar J J, de Gans J et al.. Adjunctive dexamethasone in bacterial meningitis: a meta-analysis of individual patient data.  Lancet Neurol. 2010;  9 (3) 254-263
  • 22 Brouwer M C, Heckenberg S G, de Gans J, Spanjaard L, Reitsma J B, van de Beek D. Nationwide implementation of adjunctive dexamethasone therapy for pneumococcal meningitis.  Neurology. 2010;  75 (17) 1533-1539
  • 23 Brouwer M C, McIntyre P, de Gans J, Prasad K, van de Beek D. Corticosteroids for acute bacterial meningitis.  Cochrane Database Syst Rev. 2010;  (9) CD004405
  • 24 van de Beek D, Weisfelt M, de Gans J, Tunkel A R, Wijdicks E FM. Drug insight: adjunctive therapies in adults with bacterial meningitis.  Nat Clin Pract Neurol. 2006;  2 (9) 504-516
  • 25 World Health Organization .Global tuberculosis control 2010. Available at: http://www.who.int/tb/publications/global_report/2010/en/index.html Accessed June 1, 2011
  • 26 Christensen A S, Andersen A B, Thomsen V O, Andersen P H, Johansen I S. Tuberculous meningitis in Denmark: a review of 50 cases.  BMC Infect Dis. 2011;  11 47
  • 27 Centers for Disease Control and Prevention .Reported tuberculosis in the United States 2009. Available at: http://www.cdc.gov/tb/statistics/reports/2009/pdf/report2009.pdf Accessed June 1, 2011
  • 28 Ogawa S K, Smith M A, Brennessel D J, Lowy F D. Tuberculous meningitis in an urban medical center.  Medicine (Baltimore). 1987;  66 (4) 317-326
  • 29 Kent S J, Crowe S M, Yung A, Lucas C R, Mijch A M. Tuberculous meningitis: a 30-year review.  Clin Infect Dis. 1993;  17 (6) 987-994
  • 30 Girgis N I, Sultan Y, Farid Z et al.. Tuberculosis meningitis, Abbassia Fever Hospital-Naval Medical Research Unit No. 3-Cairo, Egypt, from 1976 to 1996.  Am J Trop Med Hyg. 1998;  58 (1) 28-34
  • 31 Thwaites G, Fisher M, Hemingway C, Scott G, Solomon T, Innes J. British Infection Society . British Infection Society guidelines for the diagnosis and treatment of tuberculosis of the central nervous system in adults and children.  J Infect. 2009;  59 (3) 167-187
  • 32 Dastur D K, Manghani D K, Udani P M. Pathology and pathogenetic mechanisms in neurotuberculosis.  Radiol Clin North Am. 1995;  33 (4) 733-752
  • 33 Katrak S M. Vasculitis and stroke due to tuberculosis. In: Caplan L R, ed. Uncommon Causes of Stroke. 2nd ed. New York: Cambridge University Press; 2008: 41-45
  • 34 Lammie G A, Hewlett R H, Schoeman J F, Donald P R. Tuberculous cerebrovascular disease: a review.  J Infect. 2009;  59 (3) 156-166
  • 35 Misra U K, Kalita J, Maurya P K. Stroke in tuberculous meningitis.  J Neurol Sci. 2011;  303 (1-2) 22-30
  • 36 Shukla R, Abbas A, Kumar P, Gupta R K, Jha S, Prasad K N. Evaluation of cerebral infarction in tuberculous meningitis by diffusion weighted imaging.  J Infect. 2008;  57 (4) 298-306
  • 37 Donald P R, Schoeman J F. Tuberculous meningitis.  N Engl J Med. 2004;  351 (17) 1719-1720
  • 38 Kalita J, Misra U K, Nair P P. Predictors of stroke and its significance in the outcome of tuberculous meningitis.  J Stroke Cerebrovasc Dis. 2009;  18 (4) 251-258
  • 39 Dalal P M, Dalal K P. Subcortical and lacunar infarctions in neurotuberculosis. In: Donnan G A, Norrving B, Bamford J M, Bogousslvsky J, eds. Lacunar and Other Subcortical Infarctions. New York: Oxford University Press; 1995: 219-230
  • 40 Rich A R, McCordock H A. The pathogenesis of tuberculous meningitis.  Bull Johns Hopkins Hosp. 1933;  53 5-37
  • 41 Brown E, Gray F. Bacterial infections. In: Love S, Louis D N, Ellison D W, eds. Greenfield's Neuropathology. 8th ed. London: Hodder Arnold; 2008: 1391-1445
  • 42 Dalal P M. Observations on the involvement of cerebral vessels in tuberculous meningitis in adults.  Adv Neurol. 1979;  25 149-159
  • 43 Rojas-Echeverri L A, Soto-Hernández J L, Garza S et al.. Predictive value of digital subtraction angiography in patients with tuberculous meningitis.  Neuroradiology. 1996;  38 (1) 20-24
  • 44 Sütlaş P N, Unal A, Forta H, Senol S, Kirbaş D. Tuberculous meningitis in adults: review of 61 cases.  Infection. 2003;  31 (6) 387-391
  • 45 Jeren T, Beus I. Characteristics of cerebrospinal fluid in tuberculous meningitis.  Acta Cytol. 1982;  26 (5) 678-680
  • 46 Thwaites G E, Chau T T, Stepniewska K et al.. Diagnosis of adult tuberculous meningitis by use of clinical and laboratory features.  Lancet. 2002;  360 (9342) 1287-1292
  • 47 Zuger A. Tuberculosis. In: Scheld W M, Whitley R J, Marra C M, eds. Infections of the Central Nervous System. 3rd ed. Philadelphia: Lippincott Williams and Wilkins; 2004: 441-459
  • 48 Verdon R, Chevret S, Laissy J P, Wolff M. Tuberculous meningitis in adults: review of 48 cases.  Clin Infect Dis. 1996;  22 (6) 982-988
  • 49 Thwaites G E, Chau T T, Farrar J J. Improving the bacteriological diagnosis of tuberculous meningitis.  J Clin Microbiol. 2004;  42 (1) 378-379
  • 50 Thwaites G E, Caws M, Chau T T et al.. Comparison of conventional bacteriology with nucleic acid amplification (amplified mycobacterium direct test) for diagnosis of tuberculous meningitis before and after inception of antituberculosis chemotherapy.  J Clin Microbiol. 2004;  42 (3) 996-1002
  • 51 Pai M, Flores L L, Pai N, Hubbard A, Riley L W, Colford Jr J M. Diagnostic accuracy of nucleic acid amplification tests for tuberculous meningitis: a systematic review and meta-analysis.  Lancet Infect Dis. 2003;  3 (10) 633-643
  • 52 Hsieh F Y, Chia L G, Shen W C. Locations of cerebral infarctions in tuberculous meningitis.  Neuroradiology. 1992;  34 (3) 197-199
  • 53 Nair P P, Kalita J, Kumar S, Misra U K. MRI pattern of infarcts in basal ganglia region in patients with tuberculous meningitis.  Neuroradiology. 2009;  51 (4) 221-225
  • 54 Greitz T. Angiography in tuberculous meningitis.  Acta Radiol Diagn (Stockh). 1964;  2 369-378
  • 55 Lehrer H. The angiographic triad in tuberculous meningitis. A radiographic and clinicopathologic correlation.  Radiology. 1966;  87 (5) 829-835
  • 56 Mathew N T, Abraham J, Chandy J. Cerebral angiographic features in tuberculous meningitis.  Neurology. 1970;  20 (10) 1015-1023
  • 57 Koh S B, Kim B J, Park M H, Yu S W, Park K W, Lee D H. Clinical and laboratory characteristics of cerebral infarction in tuberculous meningitis: a comparative study.  J Clin Neurosci. 2007;  14 (11) 1073-1077
  • 58 Misra U K, Kalita J, Roy A K, Mandal S K, Srivastava M. Role of clinical, radiological, and neurophysiological changes in predicting the outcome of tuberculous meningitis: a multivariable analysis.  J Neurol Neurosurg Psychiatry. 2000;  68 (3) 300-303
  • 59 Berenguer J, Moreno S, Laguna F et al.. Tuberculous meningitis in patients infected with the human immunodeficiency virus.  N Engl J Med. 1992;  326 (10) 668-672
  • 60 Dubé M P, Holtom P D, Larsen R A. Tuberculous meningitis in patients with and without human immunodeficiency virus infection.  Am J Med. 1992;  93 (5) 520-524
  • 61 Porkert M T, Sotir M, Parrott-Moore P, Blumberg H M. Tuberculous meningitis at a large inner-city medical center.  Am J Med Sci. 1997;  313 (6) 325-331
  • 62 Yechoor V K, Shandera W X, Rodriguez P, Cate T R. Tuberculous meningitis among adults with and without HIV infection. Experience in an urban public hospital.  Arch Intern Med. 1996;  156 (15) 1710-1716
  • 63 Schutte C M. Clinical, cerebrospinal fluid and pathological findings and outcomes in HIV-positive and HIV-negative patients with tuberculous meningitis.  Infection. 2001;  29 (4) 213-217
  • 64 van der Weert E M, Hartgers N M, Schaaf H S et al.. Comparison of diagnostic criteria of tuberculous meningitis in human immunodeficiency virus-infected and uninfected children.  Pediatr Infect Dis J. 2006;  25 (1) 65-69
  • 65 Jarvis J N, Meintjes G, Williams A, Brown Y, Crede T, Harrison T S. Adult meningitis in a setting of high HIV and TB prevalence: findings from 4961 suspected cases.  BMC Infect Dis. 2010;  10 67
  • 66 Katrak S M, Shembalkar P K, Bijwe S R, Bhandarkar L D. The clinical, radiological and pathological profile of tuberculous meningitis in patients with and without human immunodeficiency virus infection.  J Neurol Sci. 2000;  181 (1-2) 118-126
  • 67 Thwaites G E, Duc Bang N, Huy Dung N et al.. The influence of HIV infection on clinical presentation, response to treatment, and outcome in adults with tuberculous meningitis.  J Infect Dis. 2005;  192 (12) 2134-2141
  • 68 Jones B E, Young S M, Antoniskis D, Davidson P T, Kramer F, Barnes P F. Relationship of the manifestations of tuberculosis to CD4 cell counts in patients with human immunodeficiency virus infection.  Am Rev Respir Dis. 1993;  148 (5) 1292-1297
  • 69 American Thoracic Society . Treatment of tuberculosis.  MMWR Recomm Rep. 2003;  52 (RR-11) 1-77
  • 70 Thwaites G E, Nguyen D B, Nguyen H D et al.. Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults.  N Engl J Med. 2004;  351 (17) 1741-1751
  • 71 Prasad K, Singh M B. Corticosteroids for managing tuberculous meningitis.  Cochrane Database Syst Rev. 2008;  (1) CD002244
  • 72 Marais S, Pepper D J, Schutz C, Wilkinson R J, Meintjes G. Presentation and outcome of tuberculous meningitis in a high HIV prevalence setting.  PLoS ONE. 2011;  6 (5) e20077
  • 73 Teoh R, Humphries M J, O'Mahony G. Symptomatic intracranial tuberculoma developing during treatment of tuberculosis: a report of 10 patients and review of the literature.  Q J Med. 1987;  63 (241) 449-460
  • 74 Narita M, Ashkin D, Hollender E S, Pitchenik A E. Paradoxical worsening of tuberculosis following antiretroviral therapy in patients with AIDS.  Am J Respir Crit Care Med. 1998;  158 (1) 157-161
  • 75 Pepper D J, Marais S, Maartens G et al.. Neurologic manifestations of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome: a case series.  Clin Infect Dis. 2009;  48 (11) e96-e107
  • 76 Thwaites G E, Macmullen-Price J, Tran T H et al.. Serial MRI to determine the effect of dexamethasone on the cerebral pathology of tuberculous meningitis: an observational study.  Lancet Neurol. 2007;  6 (3) 230-236
  • 77 Misra U K, Kalita J, Nair P P. Role of aspirin in tuberculous meningitis: a randomized open label placebo controlled trial.  J Neurol Sci. 2010;  293 (1-2) 12-17
  • 78 CDC .Syphilis. Sexually Transmitted Diseases 2009. Available at: http://www.cdc.gov/std/stats09/syphilis.htm Accessed May 25, 2011
  • 79 Lukehart S A, Hook III E W, Baker-Zander S A, Collier A C, Critchlow C W, Handsfield H H. Invasion of the central nervous system by Treponema pallidum: implications for diagnosis and treatment.  Ann Intern Med. 1988;  109 (11) 855-862
  • 80 Rolfs R T, Joesoef M R, Hendershot E F The Syphilis and HIV Study Group et al. A randomized trial of enhanced therapy for early syphilis in patients with and without human immunodeficiency virus infection.  N Engl J Med. 1997;  337 (5) 307-314
  • 81 Merrit H H, Adams R D, Solomon H C. Neurosyphilis. New York: Oxford University Press; 1946
  • 82 Burke J M, Schaberg D R. Neurosyphilis in the antibiotic era.  Neurology. 1985;  35 (9) 1368-1371
  • 83 Stokes J H, Beerman H, Ingraham N R. Modern Clinical Sphilology: Diagnosis, Treatment, Case Study. Philadelphia: WB Saunders; 1944
  • 84 Timmermans M, Carr J. Neurosyphilis in the modern era.  J Neurol Neurosurg Psychiatry. 2004;  75 (12) 1727-1730
  • 85 Musher D M. Syphilis, neurosyphilis, penicillin, and AIDS.  J Infect Dis. 1991;  163 (6) 1201-1206
  • 86 Holmes M D, Brant-Zawadzki M M, Simon R P. Clinical features of meningovascular syphilis.  Neurology. 1984;  34 (4) 553-556
  • 87 Harriman D GF. Bacterial infections of the central nervous system. In: Blackwood W, Corsellis J AN, eds. Greenfield's Neuropathology. 3rd ed. Chicago: Yearbook Medical Publishers; 1976: 238-268
  • 88 Vatz K A, Scheibel R L, Keiffer S A, Ansari K A. Neurosyphilis and diffuse cerebral angiopathy: a case report.  Neurology. 1974;  24 (5) 472-476
  • 89 Winkelman N W, Eckel J L. Productive endarteritis of the small cortical vessels in severe toxemias.  Brain. 1927;  50 (3–4) 608-623
  • 90 Davis L E, Schmitt J W. Clinical significance of cerebrospinal fluid tests for neurosyphilis.  Ann Neurol. 1989;  25 (1) 50-55
  • 91 Workowski K A, Berman S M. Centers for Disease Control and Prevention . Sexually transmitted diseases treatment guidelines, 2006.  MMWR Recomm Rep. 2006;  55 (RR-11) 1-94
  • 92 Jaffe H W, Larsen S A, Peters M, Jove D F, Lopez B, Schroeter A L. Tests for treponemal antibody in CSF.  Arch Intern Med. 1978;  138 (2) 252-255
  • 93 Simon R P. Neurosyphilis.  Arch Neurol. 1985;  42 (6) 606-613
  • 94 Marra C M, Maxwell C L, Collier A C, Robertson K R, Imrie A. Interpreting cerebrospinal fluid pleocytosis in HIV in the era of potent antiretroviral therapy.  BMC Infect Dis. 2007;  7 37
  • 95 Berry C D, Hooton T M, Collier A C, Lukehart S A. Neurologic relapse after benzathine penicillin therapy for secondary syphilis in a patient with HIV infection.  N Engl J Med. 1987;  316 (25) 1587-1589
  • 96 Johns D R, Tierney M, Felsenstein D. Alteration in the natural history of neurosyphilis by concurrent infection with the human immunodeficiency virus.  N Engl J Med. 1987;  316 (25) 1569-1572
  • 97 Katz D A, Berger J R, Duncan R C. Neurosyphilis. A comparative study of the effects of infection with human immunodeficiency virus.  Arch Neurol. 1993;  50 (3) 243-249
  • 98 Centers for Disease Control and Prevention (CDC) . Symptomatic early neurosyphilis among HIV-positive men who have sex with men—four cities, United States, January 2002-June 2004.  MMWR Morb Mortal Wkly Rep. 2007;  56 (25) 625-628
  • 99 Chang C C, Leslie D E, Spelman D et al.. Symptomatic and asymptomatic early neurosyphilis in HIV-infected men who have sex with men: a retrospective case series from 2000 to 2007.  Sex Health. 2011;  8 (2) 207-213
  • 100 Bucher J B, Golden M R, Heald A E, Marra C M. Stroke in a patient with human immunodeficiency virus and syphilis treated with penicillin and antiretroviral therapy.  Sex Transm Dis. 2010;  November 30 (Epub ahead of print)
  • 101 Marra C M, Maxwell C L, Smith S L et al.. Cerebrospinal fluid abnormalities in patients with syphilis: association with clinical and laboratory features.  J Infect Dis. 2004;  189 (3) 369-376
  • 102 Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents. 2008. Available at: http://AIDSinfo.nih.gov Accessed May 28, 2009
  • 103 Ghanem K G, Erbelding E J, Wiener Z S, Rompalo A M. Serological response to syphilis treatment in HIV-positive and HIV-negative patients attending sexually transmitted diseases clinics.  Sex Transm Infect. 2007;  83 (2) 97-101
  • 104 Kelley R E, Minagar A, Kelley B J, Brunson R. Trancranial Doppler monitoring of response to therapy for meningovascular syphilis.  J Neuroimaging. 2003;  13 (1) 85-87
  • 105 Davis L E, Graham G D. Neurosyphilis and stroke. In: Caplan L R, ed. Uncommon Causes of Stroke. 2nd ed. New York: Cambridge University Press; 2008: 35-39
  • 106 Askalan R, Laughlin S, Mayank S et al.. Chickenpox and stroke in childhood: a study of frequency and causation.  Stroke. 2001;  32 (6) 1257-1262
  • 107 Lanthier S, Armstrong D, Domi T, deVeber G. Post-varicella arteriopathy of childhood: natural history of vascular stenosis.  Neurology. 2005;  64 (4) 660-663
  • 108 Miravet E, Danchaivijitr N, Basu H, Saunders D E, Ganesan V. Clinical and radiological features of childhood cerebral infarction following varicella zoster virus infection.  Dev Med Child Neurol. 2007;  49 (6) 417-422
  • 109 Manco-Johnson M J, Nuss R, Key N et al.. Lupus anticoagulant and protein S deficiency in children with postvaricella purpura fulminans or thrombosis.  J Pediatr. 1996;  128 (3) 319-323
  • 110 Massano J, Ferreira D, Toledo T, Mansilha A, Azevedo E, Carvalho M. Stroke and multiple peripheral thrombotic events in an adult with varicella.  Eur J Neurol. 2008;  15 (10) e90-e91
  • 111 Josephson C, Nuss R, Jacobson L et al.. The varicella-autoantibody syndrome.  Pediatr Res. 2001;  50 (3) 345-352
  • 112 Amlie-Lefond C, Jubelt B. Neurologic manifestations of varicella zoster virus infections.  Curr Neurol Neurosci Rep. 2009;  9 (6) 430-434
  • 113 Reshef E, Greenberg S B, Jankovic J. Herpes zoster ophthalmicus followed by contralateral hemiparesis: report of two cases and review of literature.  J Neurol Neurosurg Psychiatry. 1985;  48 (2) 122-127
  • 114 Hilt D C, Buchholz D, Krumholz A, Weiss H, Wolinsky J S. Herpes zoster ophthalmicus and delayed contralateral hemiparesis caused by cerebral angiitis: diagnosis and management approaches.  Ann Neurol. 1983;  14 (5) 543-553
  • 115 Nagel M A, Cohrs R J, Mahalingam R et al.. The varicella zoster virus vasculopathies: clinical, CSF, imaging, and virologic features.  Neurology. 2008;  70 (11) 853-860
  • 116 Gray F, Bélec L, Lescs M C et al.. Varicella-zoster virus infection of the central nervous system in the acquired immune deficiency syndrome.  Brain. 1994;  117 (Pt 5) 987-999
  • 117 Nagel M A, Mahalingam R, Cohrs R J, Gilden D. Virus vasculopathy and stroke: an under-recognized cause and treatment target.  Infect Disord Drug Targets. 2010;  10 (2) 105-111
  • 118 Nagel M A, Forghani B, Mahalingam R et al.. The value of detecting anti-VZV IgG antibody in CSF to diagnose VZV vasculopathy.  Neurology. 2007;  68 (13) 1069-1073
  • 119 Katchanov J, Siebert E, Klingebiel R, Endres M. Infectious vasculopathy of intracranial large- and medium-sized vessels in neurological intensive care unit: a clinico-radiological study.  Neurocrit Care. 2010;  12 (3) 369-374
  • 120 Schmidbauer M, Budka H, Pilz P, Kurata T, Hondo R. Presence, distribution and spread of productive varicella zoster virus infection in nervous tissues.  Brain. 1992;  115 (Pt 2) 383-398
  • 121 Kleinschmidt-DeMasters B K, Amlie-Lefond C, Gilden D H. The patterns of varicella zoster virus encephalitis.  Hum Pathol. 1996;  27 (9) 927-938
  • 122 Ruppenthal M. Changes of the central nervous system in herpes zoster.  Acta Neuropathol. 1980;  52 (1) 59-68
  • 123 Gilden D H, Kleinschmidt-DeMasters B K, LaGuardia J J, Mahalingam R, Cohrs R J. Neurologic complications of the reactivation of varicella-zoster virus.  N Engl J Med. 2000;  342 (9) 635-645
  • 124 Gilden D, Cohrs R J, Mahalingam R, Nagel M A. Varicella zoster virus vasculopathies: diverse clinical manifestations, laboratory features, pathogenesis, and treatment.  Lancet Neurol. 2009;  8 (8) 731-740
  • 125 Newsome S D, Nath A. Varicella-zoster virus vasculopathy and central nervous system immune reconstitution inflammatory syndrome with human immunodeficiency virus infection treated with steroids.  J Neurovirol. 2009;  15 (3) 288-291
  • 126 Oxman M N, Levin M J, Johnson G R Shingles Prevention Study Group et al. A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults.  N Engl J Med. 2005;  352 (22) 2271-2284
  • 127 Triant V A, Lee H, Hadigan C, Grinspoon S K. Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease.  J Clin Endocrinol Metab. 2007;  92 (7) 2506-2512
  • 128 Currier J S, Taylor A, Boyd F et al.. Coronary heart disease in HIV-infected individuals.  J Acquir Immune Defic Syndr. 2003;  33 (4) 506-512
  • 129 Friis-Møller N, Sabin C A, Weber R Data Collection on Adverse Events of Anti-HIV Drugs (DAD) Study Group et al. Combination antiretroviral therapy and the risk of myocardial infarction.  N Engl J Med. 2003;  349 (21) 1993-2003
  • 130 Berger J R, Harris J O, Gregorios J, Norenberg M. Cerebrovascular disease in AIDS: a case-control study.  AIDS. 1990;  4 (3) 239-244
  • 131 Cole J W, Pinto A N, Hebel J R et al.. Acquired immunodeficiency syndrome and the risk of stroke.  Stroke. 2004;  35 (1) 51-56
  • 132 Engstrom J W, Lowenstein D H, Bredesen D E. Cerebral infarctions and transient neurologic deficits associated with acquired immunodeficiency syndrome.  Am J Med. 1989;  86 (5) 528-532
  • 133 Pinto A N. AIDS and cerebrovascular disease.  Stroke. 1996;  27 (3) 538-543
  • 134 Anders K H, Guerra W F, Tomiyasu U, Verity M A, Vinters H V. The neuropathology of AIDS. UCLA experience and review.  Am J Pathol. 1986;  124 (3) 537-558
  • 135 Mizusawa H, Hirano A, Llena J F, Shintaku M. Cerebrovascular lesions in acquired immune deficiency syndrome (AIDS).  Acta Neuropathol. 1988;  76 (5) 451-457
  • 136 Connor M D, Lammie G A, Bell J E, Warlow C P, Simmonds P, Brettle R D. Cerebral infarction in adult AIDS patients: observations from the Edinburgh HIV Autopsy Cohort.  Stroke. 2000;  31 (9) 2117-2126
  • 137 Gray F, Gherardi R, Scaravilli F. The neuropathology of the acquired immune deficiency syndrome (AIDS). A review.  Brain. 1988;  111 (Pt 2) 245-266
  • 138 Evers S, Nabavi D, Rahmann A, Heese C, Reichelt D, Husstedt I W. Ischaemic cerebrovascular events in HIV infection: a cohort study.  Cerebrovasc Dis. 2003;  15 (3) 199-205
  • 139 Corral I, Quereda C, Moreno A et al.. Cerebrovascular ischemic events in HIV-1-infected patients receiving highly active antiretroviral therapy: incidence and risk factors.  Cerebrovasc Dis. 2009;  27 (6) 559-563
  • 140 Berger J R. AIDS and stroke risk.  Lancet Neurol. 2004;  3 (4) 206-207
  • 141 Ovbiagele B, Nath A. Increasing incidence of ischemic stroke in patients with HIV infection.  Neurology. 2011;  January 19 (Epub ahead of print)
  • 142 Chetty R. Vasculitides associated with HIV infection.  J Clin Pathol. 2001;  54 (4) 275-278
  • 143 Calabrese L H, Estes M, Yen-Lieberman B et al.. Systemic vasculitis in association with human immunodeficiency virus infection.  Arthritis Rheum. 1989;  32 (5) 569-576
  • 144 Calabrese L H. Vasculitis and infection with the human immunodeficiency virus.  Rheum Dis Clin North Am. 1991;  17 (1) 131-147
  • 145 Anders K H, Latta H, Chang B S, Tomiyasu U, Quddusi A S, Vinters H V. Lymphomatoid granulomatosis and malignant lymphoma of the central nervous system in the acquired immunodeficiency syndrome.  Hum Pathol. 1989;  20 (4) 326-334
  • 146 Calabrese L H. Infection with the human immunodeficiency virus type 1 and vascular inflammatory disease.  Clin Exp Rheumatol. 2004;  22 (6, Suppl 36) S87-S93
  • 147 Nogueras C, Sala M, Sasal M et al.. Recurrent stroke as a manifestation of primary angiitis of the central nervous system in a patient infected with human immunodeficiency virus.  Arch Neurol. 2002;  59 (3) 468-473
  • 148 Melica G, Brugieres P, Lascaux A S, Levy Y, Lelièvre J D. Primary vasculitis of the central nervous system in patients infected with HIV-1 in the HAART era.  J Med Virol. 2009;  81 (4) 578-581
  • 149 Frank Y, Lim W, Kahn E, Farmer P, Gorey M, Pahwa S. Multiple ischemic infarcts in a child with AIDS, varicella zoster infection, and cerebral vasculitis.  Pediatr Neurol. 1989;  5 (1) 64-67
  • 150 Yankner B A, Skolnik P R, Shoukimas G M, Gabuzda D H, Sobel R A, Ho D D. Cerebral granulomatous angiitis associated with isolation of human T-lymphotropic virus type III from the central nervous system.  Ann Neurol. 1986;  20 (3) 362-364
  • 151 Bhagavati S, Choi J. Rapidly progressive cerebrovascular stenosis and recurrent strokes followed by improvement in HIV vasculopathy.  Cerebrovasc Dis. 2008;  26 (4) 449-452
  • 152 Gillams A R, Allen E, Hrieb K, Venna N, Craven D, Carter A P. Cerebral infarction in patients with AIDS.  AJNR Am J Neuroradiol. 1997;  18 (8) 1581-1585
  • 153 Vinters H V, Guerra W F, Eppolito L, Keith III P E. Necrotizing vasculitis of the nervous system in a patient with AIDS-related complex.  Neuropathol Appl Neurobiol. 1988;  14 (5) 417-424
  • 154 Scaravilli F, Daniel S E, Harcourt-Webster N, Guiloff R J. Chronic basal meningitis and vasculitis in acquired immunodeficiency syndrome. A possible role for human immunodeficiency virus.  Arch Pathol Lab Med. 1989;  113 (2) 192-195
  • 155 Burns D K. The neuropathology of pediatric acquired immunodeficiency syndrome.  J Child Neurol. 1992;  7 (4) 332-346
  • 156 Park Y D, Belman A L, Kim T S et al.. Stroke in pediatric acquired immunodeficiency syndrome.  Ann Neurol. 1990;  28 (3) 303-311
  • 157 Dubrovsky T, Curless R, Scott G et al.. Cerebral aneurysmal arteriopathy in childhood AIDS.  Neurology. 1998;  51 (2) 560-565
  • 158 Martínez-Longoria C A, Morales-Aguirre J J, Villalobos-Acosta C P, Gómez-Barreto D, Cashat-Cruz M. Occurrence of intracerebral aneurysm in an HIV-infected child: a case report.  Pediatr Neurol. 2004;  31 (2) 130-132
  • 159 Mazzoni P, Chiriboga C A, Millar W S, Rogers A. Intracerebral aneurysms in human immunodeficiency virus infection: case report and literature review.  Pediatr Neurol. 2000;  23 (3) 252-255
  • 160 Patsalides A D, Wood L V, Atac G K, Sandifer E, Butman J A, Patronas N J. Cerebrovascular disease in HIV-infected pediatric patients: neuroimaging findings.  AJR Am J Roentgenol. 2002;  179 (4) 999-1003
  • 161 Chetty R, Batitang S, Nair R. Large artery vasculopathy in HIV-positive patients: another vasculitic enigma.  Hum Pathol. 2000;  31 (3) 374-379
  • 162 Tipping B, de Villiers L, Candy S, Wainwright H. Stroke caused by human immunodeficiency virus-associated intracranial large-vessel aneurysmal vasculopathy.  Arch Neurol. 2006;  63 (11) 1640-1642
  • 163 Tipping B, de Villiers L, Wainwright H, Candy S, Bryer A. Stroke in patients with human immunodeficiency virus infection.  J Neurol Neurosurg Psychiatry. 2007;  78 (12) 1320-1324
  • 164 Qureshi A I, Janssen R S, Karon J M et al.. Human immunodeficiency virus infection and stroke in young patients.  Arch Neurol. 1997;  54 (9) 1150-1153
  • 165 Mochan A, Modi M, Modi G. Stroke in black South African HIV-positive patients: a prospective analysis.  Stroke. 2003;  34 (1) 10-15
  • 166 Mochan A, Modi M, Modi G. Protein S deficiency in HIV associated ischaemic stroke: an epiphenomenon of HIV infection.  J Neurol Neurosurg Psychiatry. 2005;  76 (10) 1455-1456
  • 167 Ortiz G, Koch S, Romano J G, Forteza A M, Rabinstein A A. Mechanisms of ischemic stroke in HIV-infected patients.  Neurology. 2007;  68 (16) 1257-1261
  • 168 Stein J H. Dyslipidemia in the era of HIV protease inhibitors.  Prog Cardiovasc Dis. 2003;  45 (4) 293-304
  • 169 Walli R, Herfort O, Michl G M et al.. Treatment with protease inhibitors associated with peripheral insulin resistance and impaired oral glucose tolerance in HIV-1-infected patients.  AIDS. 1998;  12 (15) F167-F173
  • 170 Périard D, Telenti A, Sudre P et al.. Atherogenic dyslipidemia in HIV-infected individuals treated with protease inhibitors. The Swiss HIV Cohort Study.  Circulation. 1999;  100 (7) 700-705
  • 171 Carr A. HIV lipodystrophy: risk factors, pathogenesis, diagnosis and management.  AIDS. 2003;  17 (Suppl 1) S141-S148
  • 172 Chen D, Misra A, Garg A. Clinical review 153: Lipodystrophy in human immunodeficiency virus-infected patients.  J Clin Endocrinol Metab. 2002;  87 (11) 4845-4856
  • 173 Saif M W, Bona R, Greenberg B. AIDS and thrombosis: retrospective study of 131 HIV-infected patients.  AIDS Patient Care STDS. 2001;  15 (6) 311-320
  • 174 Fantoni M, Del Borgo C, Autore C. Evaluation and management of metabolic and coagulative disorders in HIV-infected patients receiving highly active antiretroviral therapy.  AIDS. 2003;  17 (Suppl 1) S162-S169
  • 175 Bozzette S A, Ake C F, Tam H K et al.. Long-term survival and serious cardiovascular events in HIV-infected patients treated with highly active antiretroviral therapy.  J Acquir Immune Defic Syndr. 2008;  47 (3) 338-341
  • 176 Currier J S, Kendall M A, Zackin R AACTG 5078 Study Team et al. Carotid artery intima-media thickness and HIV infection: traditional risk factors overshadow impact of protease inhibitor exposure.  AIDS. 2005;  19 (9) 927-933
  • 177 El-Sadr W M, Lundgren J D, Neaton J D Strategies for Management of Antiretroviral Therapy (SMART) Study Group et al. CD4 + count-guided interruption of antiretroviral treatment.  N Engl J Med. 2006;  355 (22) 2283-2296
  • 178 Mercié P, Thiébaut R, Lavignolle V et al.. Evaluation of cardiovascular risk factors in HIV-1 infected patients using carotid intima-media thickness measurement.  Ann Med. 2002;  34 (1) 55-63
  • 179 Seaberg E C, Benning L, Sharrett A R et al.. Association between human immunodeficiency virus infection and stiffness of the common carotid artery.  Stroke. 2010;  41 (10) 2163-2170
  • 180 Denning D W. Invasive aspergillosis.  Clin Infect Dis. 1998;  26 (4) 781-803 quiz 804-805
  • 181 Torre-Cisneros J, Lopez O L, Kusne S et al.. CNS aspergillosis in organ transplantation: a clinicopathological study.  J Neurol Neurosurg Psychiatry. 1993;  56 (2) 188-193
  • 182 Walsh T J, Hier D B, Caplan L R. Aspergillosis of the central nervous system: clinicopathological analysis of 17 patients.  Ann Neurol. 1985;  18 (5) 574-582
  • 183 Hori A, Kami M, Kishi Y, Machida U, Matsumura T, Kashima T. Clinical significance of extra-pulmonary involvement of invasive aspergillosis: a retrospective autopsy-based study of 107 patients.  J Hosp Infect. 2002;  50 (3) 175-182
  • 184 Kleinschmidt-DeMasters B K. Central nervous system aspergillosis: a 20-year retrospective series.  Hum Pathol. 2002;  33 (1) 116-124
  • 185 Pongbhaesaj P, Dejthevaporn C, Tunlayadechanont S, Witoonpanich R, Sungkanuparph S, Vibhagool A. Aspergillosis of the central nervous system: a catastrophic opportunistic infection.  Southeast Asian J Trop Med Public Health. 2004;  35 (1) 119-125
  • 186 Lin S J, Schranz J, Teutsch S M. Aspergillosis case-fatality rate: systematic review of the literature.  Clin Infect Dis. 2001;  32 (3) 358-366
  • 187 Denning D W. Therapeutic outcome in invasive aspergillosis.  Clin Infect Dis. 1996;  23 (3) 608-615
  • 188 Schwartz S, Thiel E. Update on the treatment of cerebral aspergillosis.  Ann Hematol. 2004;  83 (Suppl 1) S42-S44
  • 189 Sood S, Sharma R, Gupta S, Pathak D, Rishi S. Neuroaspergillosis in an immunocompetent patient.  Indian J Med Microbiol. 2007;  25 (1) 67-69
  • 190 Martins H S, da Silva T R, Scalabrini-Neto A, Velasco I T. Cerebral vasculitis caused by Aspergillus simulating ischemic stroke in an immunocompetent patient.  J Emerg Med. 2010;  38 (5) 597-600
  • 191 Murthy J M, Sundaram C, Prasad V S, Purohit A K, Rammurti S, Laxmi V. Aspergillosis of central nervous system: a study of 21 patients seen in a university hospital in south India.  J Assoc Physicians India. 2000;  48 (7) 677-681
  • 192 Ho C L, Deruytter M J. CNS aspergillosis with mycotic aneurysm, cerebral granuloma and infarction.  Acta Neurochir (Wien). 2004;  146 (8) 1-6
  • 193 Hagensee M E, Bauwens J E, Kjos B, Bowden R A. Brain abscess following marrow transplantation: experience at the Fred Hutchinson Cancer Research Center, 1984-1992.  Clin Infect Dis. 1994;  19 (3) 402-408
  • 194 Hummel M, Spiess B, Kentouche K et al.. Detection of Aspergillus DNA in cerebrospinal fluid from patients with cerebral aspergillosis by a nested PCR assay.  J Clin Microbiol. 2006;  44 (11) 3989-3993
  • 195 Kami M, Shirouzu I, Mitani K et al.. Early diagnosis of central nervous system aspergillosis with combination use of cerebral diffusion-weighted echo-planar magnetic resonance image and polymerase chain reaction of cerebrospinal fluid.  Intern Med. 1999;  38 (1) 45-48
  • 196 Wheat L J. Rapid diagnosis of invasive aspergillosis by antigen detection.  Transpl Infect Dis. 2003;  5 (4) 158-166
  • 197 Musher B, Fredricks D, Leisenring W, Balajee S A, Smith C, Marr K A. Aspergillus galactomannan enzyme immunoassay and quantitative PCR for diagnosis of invasive aspergillosis with bronchoalveolar lavage fluid.  J Clin Microbiol. 2004;  42 (12) 5517-5522
  • 198 Persat F, Ranque S, Derouin F, Michel-Nguyen A, Picot S, Sulahian A. Contribution of the (1→3)-beta-D-glucan assay for diagnosis of invasive fungal infections.  J Clin Microbiol. 2008;  46 (3) 1009-1013
  • 199 Viscoli C, Machetti M, Gazzola P et al.. Aspergillus galactomannan antigen in the cerebrospinal fluid of bone marrow transplant recipients with probable cerebral aspergillosis.  J Clin Microbiol. 2002;  40 (4) 1496-1499
  • 200 Miaux Y, Ribaud P, Williams M et al.. MR of cerebral aspergillosis in patients who have had bone marrow transplantation.  AJNR Am J Neuroradiol. 1995;  16 (3) 555-562
  • 201 Gabelmann A, Klein S, Kern W et al.. Relevant imaging findings of cerebral aspergillosis on MRI: a retrospective case-based study in immunocompromised patients.  Eur J Neurol. 2007;  14 (5) 548-555
  • 202 Hurst R W, Judkins A, Bolger W, Chu A, Loevner L A. Mycotic aneurysm and cerebral infarction resulting from fungal sinusitis: imaging and pathologic correlation.  AJNR Am J Neuroradiol. 2001;  22 (5) 858-863
  • 203 Endo T, Tominaga T, Konno H, Yoshimoto T. Fatal subarachnoid hemorrhage, with brainstem and cerebellar infarction, caused by Aspergillus infection after cerebral aneurysm surgery: case report.  Neurosurgery. 2002;  50 (5) 1147-1150 discussion 1150-1151
  • 204 Iihara K, Makita Y, Nabeshima S, Tei T, Keyaki A, Nioka H. Aspergillosis of the central nervous system causing subarachnoid hemorrhage from mycotic aneurysm of the basilar artery—case report.  Neurol Med Chir (Tokyo). 1990;  30 (8) 618-623
  • 205 Schwartz S, Ruhnke M, Ribaud P et al.. Improved outcome in central nervous system aspergillosis, using voriconazole treatment.  Blood. 2005;  106 (8) 2641-2645
  • 206 Radner A B, Witt M D, Edwards Jr J E. Acute invasive rhinocerebral zygomycosis in an otherwise healthy patient: case report and review.  Clin Infect Dis. 1995;  20 (1) 163-166
  • 207 Press G A, Weindling S M, Hesselink J R, Ochi J W, Harris J P. Rhinocerebral mucormycosis: MR manifestations.  J Comput Assist Tomogr. 1988;  12 (5) 744-749
  • 208 Calli C, Savas R, Parildar M, Pekindil G, Alper H, Yunten N. Isolated pontine infarction due to rhinocerebral mucormycosis.  Neuroradiology. 1999;  41 (3) 179-181
  • 209 Rangel-Guerra R A, Martínez H R, Sáenz C, Bosques-Padilla F, Estrada-Bellmann I. Rhinocerebral and systemic mucormycosis. Clinical experience with 36 cases.  J Neurol Sci. 1996;  143 (1-2) 19-30
  • 210 Pagano L, Ricci P, Tonso A et al.. Mucormycosis in patients with haematological malignancies: a retrospective clinical study of 37 cases. GIMEMA Infection Program (Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto).  Br J Haematol. 1997;  99 (2) 331-336
  • 211 Escobar A, Del Brutto O H. Multiple brain abscesses from isolated cerebral mucormycosis.  J Neurol Neurosurg Psychiatry. 1990;  53 (5) 431-433
  • 212 Cuadrado L M, Guerrero A, Garcia Asenjo J A, Martin F, Palau E, Garcia Urra D. Cerebral mucormycosis in two cases of acquired immunodeficiency syndrome.  Arch Neurol. 1988;  45 (1) 109-111
  • 213 Hopkins R J, Rothman M, Fiore A, Goldblum S E. Cerebral mucormycosis associated with intravenous drug use: three case reports and review.  Clin Infect Dis. 1994;  19 (6) 1133-1137
  • 214 Zarei M, Morris J, Aachi V, Gregory R, Meanock C, Brito-Babapulle F. Acute isolated cerebral mucormycosis in a patient with high grade non-Hodgkins lymphoma.  Eur J Neurol. 2000;  7 (4) 443-447
  • 215 Yousem D M, Galetta S L, Gusnard D A, Goldberg H I. MR findings in rhinocerebral mucormycosis.  J Comput Assist Tomogr. 1989;  13 (5) 878-882
  • 216 Galetta S L, Wulc A E, Goldberg H I, Nichols C W, Glaser J S. Rhinocerebral mucormycosis: management and survival after carotid occlusion.  Ann Neurol. 1990;  28 (1) 103-107
  • 217 Lazo A, Wilner H I, Metes J J. Craniofacial mucormycosis: computed tomographic and angiographic findings in two cases.  Radiology. 1981;  139 (3) 623-626
  • 218 Mischel P S, Vinters H V. Coccidioidomycosis of the central nervous system: neuropathological and vasculopathic manifestations and clinical correlates.  Clin Infect Dis. 1995;  20 (2) 400-405
  • 219 Mathisen G, Shelub A, Truong J, Wigen C. Coccidioidal meningitis: clinical presentation and management in the fluconazole era.  Medicine (Baltimore). 2010;  89 (5) 251-284
  • 220 Sobel R A, Ellis W G, Nielsen S L, Davis R L. Central nervous system coccidioidomycosis: a clinicopathologic study of treatment with and without amphotericin B.  Hum Pathol. 1984;  15 (10) 980-995
  • 221 Mathisen G, Shelub A, Truong J, Wigen C. Coccidioidal meningitis: clinical presentation and management in the fluconazole era.  Medicine (Baltimore). 2010;  89 (5) 251-284
  • 222 Williams P L, Johnson R, Pappagianis D et al.. Vasculitic and encephalitic complications associated with Coccidioides immitis infection of the central nervous system in humans: report of 10 cases and review.  Clin Infect Dis. 1992;  14 (3) 673-682
  • 223 Arsura E L, Johnson R, Penrose J et al.. Neuroimaging as a guide to predict outcomes for patients with coccidioidal meningitis.  Clin Infect Dis. 2005;  40 (4) 624-627
  • 224 de Carvalho C A, Allen J N, Zafranis A, Yates A J. Coccidioidal meningitis complicated by cerebral arteritis and infarction.  Hum Pathol. 1980;  11 (3) 293-296
  • 225 Johnson R H, Einstein H E. Coccidioidal meningitis.  Clin Infect Dis. 2006;  42 (1) 103-107
  • 226 Drake K W, Adam R D. Coccidioidal meningitis and brain abscesses: analysis of 71 cases at a referral center.  Neurology. 2009;  73 (21) 1780-1786
  • 227 Ragland A S, Arsura E, Ismail Y, Johnson R. Eosinophilic pleocytosis in coccidioidal meningitis: frequency and significance.  Am J Med. 1993;  95 (3) 254-257
  • 228 Blair J E, Coakley B, Santelli A C, Hentz J G, Wengenack N L. Serologic testing for symptomatic coccidioidomycosis in immunocompetent and immunosuppressed hosts.  Mycopathologia. 2006;  162 (5) 317-324
  • 229 Williams P L. Vasculitic complications associated with coccidioidal meningitis.  Semin Respir Infect. 2001;  16 (4) 270-279
  • 230 Galgiani J N, Ampel N M, Blair J E Infectious Diseases Society of America et al. Coccidioidomycosis.  Clin Infect Dis. 2005;  41 (9) 1217-1223
  • 231 Cortez K J, Walsh T J, Bennett J E. Successful treatment of coccidioidal meningitis with voriconazole.  Clin Infect Dis. 2003;  36 (12) 1619-1622
  • 232 Wheat L J, Batteiger B E, Sathapatayavongs B. Histoplasma capsulatum infections of the central nervous system. A clinical review.  Medicine (Baltimore). 1990;  69 (4) 244-260
  • 233 Saccente M. Central nervous system histoplasmosis.  Curr Treat Options Neurol. 2008;  10 (3) 161-167
  • 234 Carod-Artal F J, Venturini M, Gomes E, de Mello M T. [Chronic central nervous system histoplasmosis in an immunocompetent patient].  Neurologia. 2008;  23 (4) 263-268
  • 235 Wheat L J, Musial C E, Jenny-Avital E. Diagnosis and management of central nervous system histoplasmosis.  Clin Infect Dis. 2005;  40 (6) 844-852
  • 236 Mitchell D H, Sorrell T C, Allworth A M et al.. Cryptococcal disease of the CNS in immunocompetent hosts: influence of cryptococcal variety on clinical manifestations and outcome.  Clin Infect Dis. 1995;  20 (3) 611-616
  • 237 Shih C C, Chen Y C, Chang S C, Luh K T, Hsieh W C. Cryptococcal meningitis in non-HIV-infected patients.  QJM. 2000;  93 (4) 245-251
  • 238 Tjia T L, Yeow Y K, Tan C B. Cryptococcal meningitis.  J Neurol Neurosurg Psychiatry. 1985;  48 (9) 853-858
  • 239 Lan S H, Chang W N, Lu C H, Lui C C, Chang H W. Cerebral infarction in chronic meningitis: a comparison of tuberculous meningitis and cryptococcal meningitis.  QJM. 2001;  94 (5) 247-253
  • 240 Chen S, Sorrell T, Nimmo G Australasian Cryptococcal Study Group et al. Epidemiology and host- and variety-dependent characteristics of infection due to Cryptococcus neoformans in Australia and New Zealand.  Clin Infect Dis. 2000;  31 (2) 499-508
  • 241 Lane M, McBride J, Archer J. Steroid responsive late deterioration in Cryptococcus neoformans variety gattii meningitis.  Neurology. 2004;  63 (4) 713-714
  • 242 Saag M S, Graybill R J, Larsen R A Infectious Diseases Society of America et al. Practice guidelines for the management of cryptococcal disease.  Clin Infect Dis. 2000;  30 (4) 710-718
  • 243 Garcia H H, Gonzalez A E, Gilman R H. Cysticerosis Working Group in Peru . Diagnosis, treatment and control of Taenia solium cysticercosis.  Curr Opin Infect Dis. 2003;  16 (5) 411-419
  • 244 Alarcón F, Hidalgo F, Moncayo J, Viñán I, Dueñas G. Cerebral cysticercosis and stroke.  Stroke. 1992;  23 (2) 224-228
  • 245 Del Brutto O H. Cysticercosis and cerebrovascular disease: a review.  J Neurol Neurosurg Psychiatry. 1992;  55 (4) 252-254
  • 246 Scharf D. Neurocysticercosis. Two hundred thirty-eight cases from a California hospital.  Arch Neurol. 1988;  45 (7) 777-780
  • 247 Barinagarrementeria F, Cantú C. Frequency of cerebral arteritis in subarachnoid cysticercosis: an angiographic study.  Stroke. 1998;  29 (1) 123-125
  • 248 Alarcón F, Vanormelingen K, Moncayo J, Viñán I. Cerebral cysticercosis as a risk factor for stroke in young and middle-aged people.  Stroke. 1992;  23 (11) 1563-1565
  • 249 Del Brutto O, Barinagarrementeria F. Inflammatory arteriopathies and pure motor hemiplegia.  Arch Neurol. 1989;  46 (4) 361
  • 250 Rodriguez-Carbajal J, Del Brutto O H, Penagos P, Huebe J, Escobar A. Occlusion of the middle cerebral artery due to cysticercotic angiitis.  Stroke. 1989;  20 (8) 1095-1099
  • 251 Cantú C, Barinagarrementeria F. Cerebrovascular complications of neurocysticercosis. Clinical and neuroimaging spectrum.  Arch Neurol. 1996;  53 (3) 233-239
  • 252 Patel R, Jha S, Yadav R K. Pleomorphism of the clinical manifestations of neurocysticercosis.  Trans R Soc Trop Med Hyg. 2006;  100 (2) 134-141
  • 253 Bouldin A, Pinter J D. Resolution of arterial stenosis in a patient with periarterial neurocysticercosis treated with oral prednisone.  J Child Neurol. 2006;  21 (12) 1064-1067
  • 254 Cantú C, Villarreal J, Soto J L, Barinagarrementeria F. Cerebral cysticercotic arteritis: detection and follow-up by transcranial Doppler.  Cerebrovasc Dis. 1998;  8 (1) 2-7
  • 255 Viola G M, White Jr A C, Serpa J A. Hemorrhagic cerebrovascular events and neurocysticercosis: a case report and review of the literature.  Am J Trop Med Hyg. 2011;  84 (3) 402-405
  • 256 García H H, Evans C AW, Nash T E et al.. Current consensus guidelines for treatment of neurocysticercosis.  Clin Microbiol Rev. 2002;  15 (4) 747-756

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