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Arzneimittelforschung 2003; 53(7): 522-525
DOI: 10.1055/s-0031-1297143
Antibiotics · Antiviral Drugs · Chemotherapeutics · Cytostatics
Editio Cantor Verlag Aulendorf (Germany)

Synthesis and Antimicrobial Activity of Flavone-3′-carboxaldehyde Oxime Ether Derivatives

Oya Bozdag-Dündar
a   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Turkey
,
Meral Tuncbilek
a   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Turkey
,
Nurten Altanlar
b   Department of Microbiology, Faculty of Pharmacy, Ankara University, Ankara, Turkey
,
Rahmiye Ertan
a   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Turkey
› Author Affiliations
Further Information

Publication History

Publication Date:
25 December 2011 (online)

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Summary

A new series of flavonyl oxime ether derivatives (FO1-FO6) was prepared by reaction of flavone-3’-carboxaldehyde (III) with O-substituted hydroxyl amine derivatives (IV ). The synthesized compounds were tested for their in vitro antifungal and antibacterial activities. All the compounds exhibited antimicrobial activity.

Zusammenfassung

Synthese und antimikrobielle Aktivität einiger Oximether-Derivate von Flavon-3’-carboxaldehyd

Eine neue Serie von Oximether-Derivaten von Flavon (FO1-FO6) wurden durch Reaktion von Flavon-3’-carboxaldehyd (III) mit O-substituierten Hydroxylamin-Derivaten (IV ) hergestellt. Die syn-thetisierten Verbindungen wurden in vitro auf antimykotische und antibakterielle Wirkung geprüft. Alle Verbindungen zeigten antimikrobielle Wirkung.

Key words

Flavonyl oxime ethers, antifungal and antimicrobial activity, synthesis