Schlafapnoe und Glaukom

Zusammenfassung

Eine Reihe von Studien deutet auf ein gehäuftes gemeinsames Vorkommen von (Normaldruck)glaukom und dem Schlaf-Apnoe-Syndrom (SAS) hin. Es wird vermutet, dass die nächtlichen Apnoen über eine Minderung der Sauerstoffversorgung des N. opticus zur Schadensprogression beitragen können. Daher empfiehlt sich bei bestimmten Patientengruppen mit Glaukom eine SAS-Abklärung.

Abstract

Several lines of evidence suggest an association between (normal-tension) glaucoma and sleep apnoea syndrome (SAS). It is hypothesised that the glaucomatous damage may result from impaired perfusion of the optic nerve head secondary to repetitive prolonged apnoeas. Therefore, screening for SAS in suspectible glaucoma patients is recommended.

Schlüsselwörter

Glaukom - Schlaf Apnoe Syndrom - CPAP

Key words

glaucoma - sleep apnoea syndrome - CPAP

• Literatur

• 1 Flammer J, Pache M, Resink T. Vasospasm, its role in the pathogenesis of diseases with particular reference to the eye. Prog Retin Eye Res 2001; 20: 319-349
• 2 Pache M, Flammer J. A sick eye in a sick body? Systemic findings in patients with primary open angle glaucoma. Surv Ophthalmol 2006; 51: 179-212
• 3 Walsh JT, Montplaisir J. Familial glaucoma with sleep apnoea: a new syndrome?. Thorax 1982; 37: 845-849
• 4 Robert PY, Adenis JP, Tapie P et al. Eyelid hyperlaxity and obstructive sleep apnea (O.S.A.) syndrome. Eur J Ophthalmol 1997; 7: 211-215
• 5 Mojon DS, Hess CW, Goldblum D et al. High prevalence of glaucoma in patients with sleep apnea syndrome. Ophthalmology 1999; 106: 1009-1012
• 6 Mojon DS, Hess CW, Goldblum D et al. Primary open-angle glaucoma is associated with sleep apnea syndrome. Ophthalmologica 2000; 214: 115-118
• 7 Onen SH, Mouriaux F, Berramdane L et al. High prevalence of sleep-disordered breathing in patients with primary open-angle glaucoma. Acta Ophthalmol Scand 2000; 78: 638-641
• 8 Marcus DM, Costarides AP, Gokhale P et al. Sleep disorders: a risk factor for normal-tension glaucoma?. J Glaucoma 2001; 10: 177-183
• 9 Lin C, Hu C, Ho J et al. Obstructive sleep apnea and increased risk of glaucoma: a population-based matched-cohort study. Ophthalmology 2013; 120: 1559-1564
• 10 Mojon DS, Hess CW, Goldblum D et al. Normal-tension glaucoma is associated with sleep apnea syndrome. Ophthalmologica 2002; 216: 180-184
• 11 Saarelainen S, Seppala E, Laasonen K et al. Circulating endothelin-1 in obstructive sleep apnea. Endothelium 1997; 5: 115-118
• 12 Phillips BG, Narkiewicz K, Pesek CA et al. Effects of obstructive sleep apnea on endothelin-1 and blood pressure. J Hypertens 1999; 17: 61-66
• 13 Sagiv O, Fishelson-Arev T, Buckman G et al. Retinal nerve fiber layer thickness measurements by optical coherence tomography in patients with sleep apnea syndrome. Clin Experiment Ophthalmol 2013; DOI: 10.1111/ceo.12145.
• 14 Pépin J, Chiquet C, Tamisier R et al. Frequent loss of nyctohemeral rhythm of intraocular pressure restored by nCPAP treatment in patients with severe apnea. Arch Ophthalmol 2010; 128: 1257-1263
• 15 Kremmer S, Selbach JM, Ayertey HD et al. [Normal tension glaucoma, sleep apnea syndrome and nasal continuous positive airway pressure therapy–case report with a review of literature]. Klin Monatsbl Augenheilkd 2001; 218: 263-268
• 16 Kremmer S, Niederdraing N, Ayertey HD et al. Obstructive sleep apnea syndrome, normal tension glaucoma, and nCPAP therapy–a short note. Sleep 2003; 26: 161-162
• 17 Kremmer S, Kreuzfelder E, Bachor E et al. Coincidence of normal tension glaucoma, progressive sensorineural hearing loss, and elevated antiphosphatidylserine antibodies. Br J Ophthalmol 2004; 88: 1259-1262
• 18 Geyer O, Cohen N, Segev E et al. The prevalence of glaucoma in patients with sleep apnea syndrome: same as in the general population. Am J Ophthalmol 2003; 136: 1093-1096