Download PDF
Zentralbl Chir 2014; 139(5): 539-545
DOI: 10.1055/s-0034-1368632
Übersicht
Georg Thieme Verlag KG Stuttgart · New York

Aggressive Therapie der tiefen Venenthrombose – Kontra

Aggressive Treatment of Deep Vein Thrombosis – Contra
J. Beyer-Westendorf
UniversitätsGefäßCentrum und Medizinische Klink III, Bereich Angiologie, Universitätsklinikum „Carl Gustav Carus“, Dresden, Deutschland
,
K. Halbritter
UniversitätsGefäßCentrum und Medizinische Klink III, Bereich Angiologie, Universitätsklinikum „Carl Gustav Carus“, Dresden, Deutschland
› Author Affiliations
Further Information

Publication History

Publication Date:
14 October 2014 (online)

Also available at
    Permissions and Reprints

Zusammenfassung

Neben der klassischen konservativen Therapie und der selten notwendigen chirurgischen Therapie werden kathetergestützte Lyseverfahren zunehmend häufiger in der Therapie der akuten tiefen Venenthrombose eingesetzt. Unser Reviewartikel beleuchtet die Datenlage zu diesem Verfahren kritisch und ist als „Kontra“-Standpunkt, als Gegenüberstellung zum ebenfalls in diesem Heft erscheinenden „Pro“-Artikel zu verstehen.

Abstract

Together with the classical conservative treatment or the rarely necessary surgical thrombectomy in patients with acute deep vein thrombosis, catheter-directed thrombolysis is becoming more and more popular. This review provides a critical view on the evidence for catheter-directed thrombolysis providing a “Contra” position in contrast to the “Pro” position also published in this issue.

Schlüsselwörter

Antikoagulation - endovaskuläre Therapie - tiefe Venenthrombose - Ulcus cruris

Key words

anticoagulation - endovascular treatment - deep vein thrombosis - venous ulcer
 

  • Literatur

  • 1 Naess IA, Christiansen SC, Romundstad P et al. Incidence and mortality of venous thrombosis: a population-based study. J Thromb Haemost 2007; 5: 692-699
    CrossrefPubMedGoogle Scholar
  • 2 Heit JA. The epidemiology of venous thromboembolism in the community. Arterioscler Thromb Vasc Biol 2008; 28: 370-372
    CrossrefPubMedGoogle Scholar
  • 3 White RH. The epidemiology of venous thromboembolism. Circulation 2003; 107: 4-8
    PubMedGoogle Scholar
  • 4 Wells PS, Forster AJ. Thrombolysis in deep vein thrombosis: is there still an indication?. Thromb Haemost 2001; 86: 499-508
    PubMedGoogle Scholar
  • 5 Goldhaber SZ, Hirsch DR, MacDougall RC et al. Bolus recombinant urokinase versus heparin in deep venous thrombosis: a randomized controlled trial. Am Heart J 1996; 132: 314-318
    CrossrefPubMedGoogle Scholar
  • 6 Kiil J, Carvalho A, Sakso P et al. Urokinase or heparin in the management of patients with deep vein thrombosis?. Acta Chir Scand 1981; 147: 529-532
    PubMedGoogle Scholar
  • 7 Schwieder G, Grimm W, Siemens HJ et al. Intermittent regional therapy with rt-PA is not superior to systemic thrombolysis in deep vein thrombosis (DVT)–a German multicenter trial. Thromb Haemost 1995; 74: 1240-1243
    PubMedGoogle Scholar
  • 8 Watson LI, Armon MP. Thrombolysis for acute deep vein thrombosis. Cochrane Database Syst Rev 2004; (4) CD002783
    PubMedGoogle Scholar
  • 9 Buller HR, Agnelli G, Hull RD et al. Antithrombotic therapy for venous thromboembolic disease: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004; 126 (Suppl. 03) S401-S428
    CrossrefPubMedGoogle Scholar
  • 10 Kearon C, Akl EA, Comerota AJ et al. Antithrombotic therapy for VTE disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012; 141 (Suppl. 02) e419S-494S
    PubMedGoogle Scholar
  • 11 Gogalniceanu P, Johnston CJ, Khalid U et al. Indications for thrombolysis in deep venous thrombosis. Eur J Vasc Endovasc Surg 2009; 38: 192-198
    CrossrefPubMedGoogle Scholar
  • 12 Linkins LA, Choi PT, Douketis JD. Clinical impact of bleeding in patients taking oral anticoagulant therapy for venous thromboembolism: a meta-analysis. Ann Intern Med 2003; 139: 893-900
    CrossrefPubMedGoogle Scholar
  • 13 Le Gal G, Carrier M, Kovacs MJ et al. Residual vein obstruction as a predictor for recurrent thromboembolic events after a first unprovoked episode: data from the REVERSE cohort study. J Thromb Haemost 2011; 9: 1126-1132
    CrossrefPubMedGoogle Scholar
  • 14 Kahn SR. Post-thrombotic syndrome after deep venous thrombosis: risk factors, prevention, and therapeutic options. Clin Adv Hematol Oncol 2009; 7: 433-435
    PubMedGoogle Scholar
  • 15 Prandoni P, Lensing AW, Prins MH et al. Below-knee elastic compression stockings to prevent the post-thrombotic syndrome: a randomized, controlled trial. Ann Intern Med 2004; 141: 249-256
    CrossrefPubMedGoogle Scholar
  • 16 Lindner DJ, Edwards JM, Phinney ES et al. Long-term hemodynamic and clinical sequelae of lower extremity deep vein thrombosis. J Vasc Surg 1986; 4: 436-442
    CrossrefPubMedGoogle Scholar
  • 17 Strandness Jr. DE, Langlois Y, Cramer M et al. Long-term sequelae of acute venous thrombosis. JAMA 1983; 250: 1289-1292
    CrossrefPubMedGoogle Scholar
  • 18 Kahn SR, Ginsberg JS. The post-thrombotic syndrome: current knowledge, controversies, and directions for future research. Blood Rev 2002; 16: 155-165
    CrossrefPubMedGoogle Scholar
  • 19 Brandjes DPM, Büller HR, Heijboer H et al. Randomized trial of effect of compression stockings in patients with symptomatic proximal-vein thrombosis. Lancet 1997; 349: 759-762
    CrossrefPubMedGoogle Scholar
  • 20 Parikh S, Motarjeme A, McNamara T et al. Ultrasound-accelerated thrombolysis for the treatment of deep vein thrombosis: initial clinical experience. J Vasc Interv Radiol 2008; 19: 521-528
    CrossrefPubMedGoogle Scholar
  • 21 Lin PH, Zhou W, Dardik A et al. Catheter-direct thrombolysis versus pharmacomechanical thrombectomy for treatment of symptomatic lower extremity deep venous thrombosis. Am J Surg 2006; 192: 782-788
    CrossrefPubMedGoogle Scholar
  • 22 Elsharawy M, Elzayat E. Early results of thrombolysis vs. anticoagulation in iliofemoral venous thrombosis. A randomised clinical trial. Eur J Vasc Endovasc Surg 2002; 24: 209-214
    CrossrefPubMedGoogle Scholar
  • 23 AbuRahma AF, Perkins SE, Wulu JT et al. Iliofemoral deep vein thrombosis: conventional therapy versus lysis and percutaneous transluminal angioplasty and stenting. Ann Surg 2001; 233: 752-760
    CrossrefPubMedGoogle Scholar
  • 24 Sharifi M, Mehdipour M, Bay C et al. Endovenous therapy for deep venous thrombosis: the TORPEDO trial. Catheter Cardiovasc Interv 2010; 76: 316-325
    CrossrefPubMedGoogle Scholar
  • 25 Enden T, Haig Y, Klow NE et al. Long-term outcome after additional catheter-directed thrombolysis versus standard treatment for acute iliofemoral deep vein thrombosis (the CaVenT study): a randomised controlled trial. Lancet 2012; 379: 31-38
    CrossrefPubMedGoogle Scholar
  • 26 Comerota AJ, Grewal N, Martinez JT et al. Postthrombotic morbidity correlates with residual thrombus following catheter-directed thrombolysis for iliofemoral deep vein thrombosis. J Vasc Surg 2012; 55: 768-773
    CrossrefPubMedGoogle Scholar
  • 27 Agnelli G, Gallus A, Goldhaber SZ et al. Treatment of proximal deep-vein thrombosis with the oral direct factor Xa inhibitor rivaroxaban (BAY 59-7939): the ODIXa-DVT (Oral Direct Factor Xa Inhibitor BAY 59-7939 in Patients With Acute Symptomatic Deep-Vein Thrombosis) study. Circulation 2007; 116: 180-187
    CrossrefPubMedGoogle Scholar
  • 28 Agnelli G, Verso M, Ageno W et al. The MASTER registry on venous thromboembolism: description of the study cohort. Thromb Res 2008; 121: 605-610
    CrossrefPubMedGoogle Scholar
  • 29 Ruiz-Gimenez N, Suarez C, Gonzalez R et al. Predictive variables for major bleeding events in patients presenting with documented acute venous thromboembolism. Findings from the RIETE Registry. Thromb Haemost 2008; 100: 26-31
    PubMedGoogle Scholar
  • 30 Agnelli G, Buller HR, Cohen A et al. Oral apixaban for the treatment of acute venous thromboembolism. N Engl J Med 2013; 369: 799-808
    CrossrefPubMedGoogle Scholar
  • 31 Bauersachs R, Berkowitz SD, Brenner B et al. Oral rivaroxaban for symptomatic venous thromboembolism. N Engl J Med 2010; 363: 2499-2510
    CrossrefPubMedGoogle Scholar
  • 32 Schulman S, Kearon C, Kakkar AK et al. Dabigatran versus warfarin in the treatment of acute venous thromboembolism. N Engl J Med 2009; 361: 2342-2352
    CrossrefPubMedGoogle Scholar
  • 33 Buller HR, Decousus H, Grosso MA et al. Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism. N Engl J Med 2013; 369: 1406-1415
    CrossrefPubMedGoogle Scholar
  • 34 Donadini MP, Ageno W, Antonucci E et al. Prognostic significance of residual venous obstruction in patients with treated unprovoked deep vein thrombosis. A patient-level meta-analysis. Thromb Haemost 2014; 111: 172-179
    PubMedGoogle Scholar
  • 35 Baldwin MJ, Moore HM, Rudarakanchana N et al. Post-thrombotic syndrome: a clinical review. J Thromb Haemost 2013; 11: 795-805
    CrossrefPubMedGoogle Scholar
  • 36 Soosainathan A, Moore HM, Gohel MS et al. Scoring systems for the post-thrombotic syndrome. J Vasc Surg 2013; 57: 254-261
    CrossrefPubMedGoogle Scholar
  • 37 Schwarz T, Schmidt B, Beyer J et al. Eligibility for home treatment of deep vein thrombosis: a prospective study in 202 consecutive patients. J Vasc Surg 2001; 34: 1065-1070
    CrossrefPubMedGoogle Scholar
  • 38 Schwarz T, Schmidt B, Hohlein U et al. Eligibility for home treatment of deep vein thrombosis: prospective study. BMJ 2001; 322: 1212-1213
    CrossrefPubMedGoogle Scholar
  • 39 Hach-Wunderle V. Diagnostik und Therapie der Venenthrombose und der Lungenembolie. AWMF-Leitlinienregister 065/002 2010. Im Internet: http://www.awmf.org/leitlinien/detail/ll/065-002.html Stand: 04. 01. 2014
    PubMedGoogle Scholar