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Journal of Pediatric Neurology 2005; 03(04): 273-275
DOI: 10.1055/s-0035-1557275
Case Report
Georg Thieme Verlag KG Stuttgart – New York

Relevance of the blood-brain barrier on compartmental pharmacokinetics of paracetamol

Karel Allegaert
a   Neonatal Intensive Care Unit, Department of Pediatrics, University Hospital, Gasthuisberg, Leuven, Belgium
,
Hugo Devlieger
a   Neonatal Intensive Care Unit, Department of Pediatrics, University Hospital, Gasthuisberg, Leuven, Belgium
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Publication History

13 October 2004

06 February 2005

Publication Date:
29 July 2015 (online)

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Abstract

Cerebrospinal fluid and plasma pharmacokinetics of paracetamol in one full term neonate are described. The observed impact of the blood-brain barrier of paracetamol on the compartmental pharmacokinetics and the pharmacodynamic relevance of this observation are discussed.

Keywords

Paracetamol - pharmacokinetics - pharmacodynamics - analgesia